CAPN1 - calpain 1 Gene

Also Known as CANP; muCL; CANP1; SPG76; CANPL1; muCANP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 823

About CAPN1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,181,373-65,212,006 (from NCBI)

This gene has 28 transcripts (splice variants), 229 orthologues, 20 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 94.2), skin (RPKM 48.8) and 24 other tissues.

Summary

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous Enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

CAPN1 Products (3)

mRNA	Protein	Name
NM_001198868.2	NP_001185797.1	calpain-1 catalytic subunit
NM_001198869.2	NP_001185798.1	calpain-1 catalytic subunit
NM_005186.4	NP_005177.2	calpain-1 catalytic subunit

CAPN1 Protein Structure

Peptidase_C2

Calpain_III

EF-hand_8

EF-hand_6

0
200
400
600
714 a.a.

Protein Preferred Names	Protein Names
calpain-1 catalytic subunit	CANP 1

CAPN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CAPN1	P07384	EZR	Homo sapiens	P15311	Protease Assay	22805611
Intra	CAPN1	P07384	CMPK1	Homo sapiens	P30085-3	Y2H Pooling	32814053
Intra	CAPN1	P07384	CMPK1	Homo sapiens	P30085-3	Validated Y2H	32814053
Intra	CAPN1	P07384	CMPK1	Homo sapiens	P30085-3	Y2H Array	32814053
Intra	CAPN1	P07384	STAT3	Homo sapiens	P40763	Y2H	21988832
Intra	CAPN1	P07384	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	CAPN1	P07384	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	CAPN1	P07384	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	CAPN1	P07384	PTPN1	Homo sapiens	P18031	ELISA	19712109
Intra	CAPN1	P07384	PTPN1	Homo sapiens	P18031	Protease Assay	19712109

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CAPN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72113	CAPN1 Protein, Human (His)	P07384 (M1-A714)	≥ 90%, as determined by reducing SDS-PAGE.

CAPN1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80443	Calpain 1 Antibody (YA815)	ICC/IF, IHC-P, FC	Human, Mouse, Rat
HY-P83990	Calpain 1 Antibody (YA3687)	WB, IHC-P, FC, ELISA	Human
HY-P83990A	Calpain 1 Antibody (YA3687)(PBS only)	WB, IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Spastic Paraplegia 76, Autosomal Recessive	SPG76 Autosomal Recessive Spastic Paraplegia Type 76 Hereditary Spastic Paraplegia 76 Autosomal Recessive Spastic Paraplegia 76 Paraplegia, Spastic, Autosomal Recessive, Type 76
Paraplegia	Paraplegia, Lower Severe Or Complete Loss Of Motor Function In The Lower Extremities And Lower Portions Of The Trunk
Spasticity
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Spastic Paraplegia 79, Autosomal Recessive	Early-Onset Progressive Neurodegeneration-Blindness-Ataxia-Spasticity Syndrome SPG79 Neurodegeneration With Optic Atrophy, Childhood-Onset Ndgoa Hereditary Spastic Paraplegia 79 Spastic Paraplegia 79 Autosomal Recessive Doid:0112344 Neurodegeneration, With Optic Atrophy, Childhood-Onset
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2a	Leyden-Moebius Muscular Dystrophy Lgmd2a Limb-Girdle Muscular Dystrophy Due To Calpain Deficiency Muscular Dystrophy, Limb-Girdle, Type 2a Pelvofemoral Muscular Dystrophy Primary Calpainopathy
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Autosomal Recessive Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Spastic Ataxia	Spax Ataxia, Spastic
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158022	CTSL/CAPN1-IN-1	Inhibitor	/	Unkown
HY-161342	CTSL/CAPN1-IN-2	Inhibitor	/	Unkown
HY-RS01883	CAPN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01895	CAPNS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17903	Capn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24372	Capn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CAPN1	VGNC	VGNC:70529
Rattus norvegicus	CAPN1	RGD	RGD:2267
Mus musculus	CAPN1	MGD	MGI:88263
Felis catus	CAPN1	VGNC	VGNC:60348
Bos taurus	CAPN1	VGNC	VGNC:26740
Canis familiaris	CAPN1	VGNC	VGNC:38698
Others	CAPN1	NCBI