TRRAP - transformation/transcription domain associated protein Gene

Homo sapiens

Also known as Tra1; TR-AP; DEDDFA; DFNA75; PAF400; STAF40; PAF350/400

Gene ID: 8295 | Gene type: protein coding

About TRRAP

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:98,878,532-99,013,241 (from NCBI)

This gene has 14 transcripts (splice variants), 242 orthologues, 5 paralogues and is associated with 118 phenotypes. Ubiquitous expression in testis (RPKM 10.2), ovary (RPKM 8.3) and 25 other tissues.

Summary

This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many Histone Acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of Cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

TRRAP Products(3)

mRNA	Protein	Name
NM_001244580.2	NP_001231509.1	transformation/transcription domain-associated protein isoform 1
NM_001375524.1	NP_001362453.1	transformation/transcription domain-associated protein isoform 3
NM_003496.4	NP_003487.1	transformation/transcription domain-associated protein isoform 2

TRRAP Protein Structure

FAT

PI3_PI4_kinase

0
600
1200
1800
2400
3000
3600
3859 a.a.

Protein Preferred Names

Protein Names

transformation/transcription domain-associated protein

350/400 kDa PCAF-associated factor

Related Diseases

Diseases

Alias

Developmental Delay With Or Without Dysmorphic Facies And Autism

DEDDFA

Deafness, Autosomal Dominant 75

DFNA75

Deafness, Autosomal Dominant, 75

Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Deafness Type Dfna	Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna
Autosomal Dominant Isolated Sensorineural Deafness Type Dfna	Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna
Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna	Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna
Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Hemangioma Of Spleen

Splenic Hemangioma

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N12487	TRRAP-IN-1		/	Unkown
HY-RS15127	TRRAP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRRAP	VGNC	VGNC:66601
Bos taurus	TRRAP	VGNC	VGNC:36403
Mus musculus	TRRAP	MGD	MGI:2153272
Macaca mulatta	TRRAP	VGNC	VGNC:78657
Rattus norvegicus	TRRAP	RGD	RGD:1305446
Canis familiaris	TRRAP	VGNC	VGNC:47887

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