SPINK7 - serine peptidase inhibitor Kazal type 7 Gene

Also Known as ECG2; ECRG2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84651

About SPINK7

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:148,312,423-148,315,919 (from NCBI)

This gene has 6 transcripts (splice variants), 101 orthologues and 5 paralogues. Restricted expression toward esophagus (RPKM 102.7).

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

SPINK7 Products (1)

mRNA Protein Name
NM_032566.3 NP_115955.1 serine protease inhibitor Kazal-type 7 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12646258 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPINK7 Protein Structure

Kazal_1

Kazal_1: Kazal-type serine protease inhibitor domain (32 - 85)

  • 0
  • 85 a.a.
Protein Preferred Names Protein Names

serine protease inhibitor Kazal-type 7

  • ECRG-2

SPINK7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPINK7 P58062 q8izw4_human Homo sapiens Q8IZW4
Y2H
12970870
Intra
SPINK7 P58062 MT1G Homo sapiens P13640
Y2H
12970870
Intra
SPINK7 P58062 EPB42 Homo sapiens P16452
Y2H
12646258
Intra
SPINK7 P58062 MT1H Homo sapiens P80294
Y2H
12970870
Intra
SPINK7 P58062 MT1H Homo sapiens P80294
Y2H
12646258
Intra
SPINK7 P58062 MRPS12 Homo sapiens O15235
Y2H
12970870
Intra
SPINK7 P58062 RABL6 Homo sapiens Q3YEC7
Y2H
12646258
Intra
SPINK7 P58062 RABL6 Homo sapiens Q3YEC7
Y2H
12970870
Intra
SPINK7 P58062 MT2A Homo sapiens P02795
Y2H
12970870
Intra
SPINK7 P58062 MT2A Homo sapiens P02795
Confocal
12646258
Intra
SPINK7 P58062 MT2A Homo sapiens P02795
Pull Down
12646258
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPINK7 Proteins

Cat. No. Product Name Accession Purity
HY-P71331 SPINK7 Protein, Human (HEK293, His) P58062 (S20-C85) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13684 SPINK7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19529 Spink7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26024 Spink7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SPINK7 RGD RGD:1303077
Macaca mulatta SPINK7 VGNC VGNC:82545
Canis familiaris SPINK7 VGNC VGNC:103707
Felis catus SPINK7 VGNC VGNC:102330
Bos taurus SPINK7 VGNC VGNC:82546
Mus musculus SPINK7 MGD MGI:3644691
Others SPINK7 NCBI