SIGLEC5 - sialic acid binding Ig like lectin 5 Gene

Also Known as CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8778

About SIGLEC5

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,610,960-51,630,401 (from NCBI)

This gene has 1 transcript (splice variant), 139 orthologues and 16 paralogues. Biased expression in bone marrow (RPKM 12.5), spleen (RPKM 10.6) and 12 other tissues.

Summary

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]

SIGLEC5 Products (3)

mRNA	Protein	Name
NM_001384708.1	NP_001371637.1	sialic acid-binding Ig-like lectin 5 isoform 2 precursor
NM_001384709.1	NP_001371638.1	sialic acid-binding Ig-like lectin 5 isoform 3 precursor
NM_003830.4	NP_003821.1	sialic acid-binding Ig-like lectin 5 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGLEC5 Protein Structure

V-set

Ig_2

0
100
200
300
400
500
551 a.a.

Protein Preferred Names	Protein Names
sialic acid-binding Ig-like lectin 5	CD33 antigen-like 2

SIGLEC5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SIGLEC5	O15389	SLC7A8	Homo sapiens	Q9UHI5	Y2H Prey Pooling	32296183
Intra	SIGLEC5	O15389	SLC7A8	Homo sapiens	Q9UHI5	Y2H Array	32296183
Intra	SIGLEC5	O15389	SLC7A8	Homo sapiens	Q9UHI5	Validated Y2H	32296183
Intra	SIGLEC5	O15389	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	SIGLEC5	O15389	VAC14	Homo sapiens	Q08AM6	Validated Y2H	32296183
Intra	SIGLEC5	O15389	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	SIGLEC5	O15389	TRIP13	Homo sapiens	Q15645	Y2H Pooling	16189514
Intra	SIGLEC5	O15389	NAPB	Homo sapiens	Q9H115	Validated Y2H	32296183
Intra	SIGLEC5	O15389	TLR4	Homo sapiens	O00206	ELISA	25187624

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIGLEC5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71023	Siglec-5 Protein, Human (HEK293, His-Flag-Fc)	O15389 (E17-T434)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72471	Siglec-5 Protein, Human (HEK293, Fc)	O15389 (E17-T434)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78203	Siglec-5 Protein, Human (Biotinylated, HEK293, Fc)	O15389 (E17-T434)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P701038	Siglec-5 Protein, Human (HEK293, His-Avi)	O15389 (E17-T434)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P701039	Siglec-5 Protein, Human (Biotinylated, HEK293, His-Avi)	O15389 (E17-T434)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Periodontitis	Chronic Pericementitis Chronic Periodontitis
Gingival Disease	Gingival Diseases Gum Disease Gingival Disorder Gingivitis And Periodontal Diseases
Gastric Signet Ring Cell Adenocarcinoma	Signet Ring Cell Gastric Adenocarcinoma Signet Ring Cell Adenocarcinoma Of The Stomach
Ovarian Cystic Teratoma
Mature Teratoma Of The Ovary
Ophthalmia Neonatorum	Gonococcal Conjunctivitis Gonococcal Ophthalmia Neonatorum Neonatal Conjunctivitis
Herpetic Whitlow	Herpetic Felon
Chorioretinal Scar	Chorioretinal Cicatrix Cicatrix Of Choroid Choroid Scar Macula Scar Macular Scarring Retinal Cicatrix Retinal Scar
Congenital Anomalies Of Kidney And Urinary Tract 2	CAKUT2 Ureteropelvic Junction Obstruction Multicystic Renal Dysplasia, Bilateral Pelviureteric Junction Obstruction Pujo Hydronephrosis Due To Pujo Upjo Mcrd Congenital Anomalies Of The Kidney And Urinary Tract 2 Mrd Pelvi-Ureteric Junction Obstruction Kidney And Urinary Tract, Anomalies, Congenital, Type 2 Obstruction Of Pelviureteric Junction
Testicular Malignant Germ Cell Cancer	Malignant Germ Cell Tumor Of Testis
Leukocyte Adhesion Deficiency, Type I	Leukocyte Adhesion Deficiency Leukocyte Adhesion Deficiency 1 LAD1 Lad Lymphocyte Function-Associated Antigen 1 Immunodeficiency Leukocyte Adhesion Deficiency Type I Leukocyte Adhesion Deficiency Type 1 Linear Iga Bullous Dermatosis Linear Iga Dermatosis Leukocyte-Adhesion Deficiency Syndrome Lfa1 Immunodeficiency Congenital Leukocyte Adherence Deficiency Lad-I Linear Iga Disease Leukocyte Adhesion Deficiency Syndrome Lad 1 Lfa 1 Immunodeficiency Linear Immunoglobulin A Dermatosis Leucocyte Adhesion Deficiency Type 1 Leukocyte Adhesion Molecule Deficiency Type 1
Salpingitis
Lemierre'S Syndrome	Lemierre Syndrome Lemierre Postanginal Sepsis Necrobacillosis Postanginal Sepsis Secondary To Orophyngeal Infection Septic Phlebitis Of The Internal Jugular Vein Fusobacterium Infections Acute Sore Throat Human Necrobacillosis Postanginal Sepsis Oropharyngeal Infection Leading To Secondary Septic Thrombophlebitis Of The Internal Jugular Vein
Von Willebrand Disease, Type 1	Von Willebrand Disease Type 1 VWD1 Von Willebrand'S Disease 1 Von Willebrand Disease Type I Von Willebrand Disease, Type I Vwd, Type 1 Vwd Type 1 Von Willebrand Disease 1 Von Willebrand Factor Deficiency Type 1 Von Willebrand Disease, Type 1, Susceptibility To
Testicular Yolk Sac Tumor	Testicular Yolk Sac Neoplasm Endodermal-Sinus Tumor Orchidoblastoma Yolk Sac Tumor
Subacute Bacterial Endocarditis	Endocarditis Lenta Sbe - Subacute Bacterial Endocarditis Subacute Endocarditis, Lenta Endocarditis, Subacute Bacterial
Mixed Glioma	Mixed Gliomas Mixed Neuroglial Tumor Glioma
Von Willebrand Disease, Type 3	Von Willebrand Disease Type 3 VWD3 Von Willebrand'S Disease 3 Von Willebrand Disease Type Iii Von Willebrand Disease, Type Iii Vwd, Type 3 Vwd Type 3 Von Willebrand Disease 3 Von Willebrand Disease Recessive Form Von Willebrand Factor Deficiency Type 3
Autoimmune Disease Of Exocrine System
Developmental And Epileptic Encephalopathy 4	DEE4 Epileptic Encephalopathy, Early Infantile, 4 Eiee4 Early Infantile Epileptic Encephalopathy 4 Stxbp1-Related Early-Onset Encephalopathy Early Myoclonic Encephalopathy Developmental And Epileptic Encephalopathy, 4 Stxbp1 Disorders Stxbp1 Encephalopathy Developmental And Epileptic Encephalopathy, Type 4 Early-Infantile Epileptic Encephalopathy 4 Stxbp1 Encephalopathy With Epilepsy Stxbp1 Epileptic Encephalopathy Stxbp1-Related Developmental And Epileptic Encephalopathy Stxbp1-Related Epileptic Encephalopathy Eme Neonatal Epilepsy With Suppression-Burst Pattern Encephalopathy, Epileptic, Early Infantile, Type 4
Neutrophilic Dermatosis, Acute Febrile	Sweet Syndrome Acute Febrile Neutrophilic Dermatosis Ss AFND Pyrin-Associated Autoinflammatory Disease PAAND Gomm-Button Disease Sweet'S Syndrome Gomm Button Disease Sweets Syndrome Acromelic Frontonasal Dysostosis Sweet Disease
Fallopian Tube Disease	Fallopian Tube Diseases
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS
Epiglottitis	Acute Epiglottitis Acute Epiglottitis And Supraglottitis Acute Epiglottiditis Epiglottiditis Epiglottitis Nos
Congenital Disorder Of Glycosylation, Type Iib	CDG2B CDGIIB Glucosidase I Deficiency Congenital Disorder Of Glycosylation Type Iib Cdg Iib Mogs-Cdg Cdg Syndrome Type Iib Cdg-Iib Carbohydrate Deficient Glycoprotein Syndrome Type Iib Congenital Disorder Of Glycosylation Type 2b Glucosidase 1 Deficiency Type Iib Congenital Disorder Of Glycosylation Glycosylation, Congenital Disorder Of, Type Iib
Von Willebrand Disease, Type 2	Von Willebrand Disease Type 2m Von Willebrand Disease Type 2 Von Willebrand Disease Type 2a Von Willebrand Disease Type 2b Von Willebrand Disease Type 2n VWD2 Von Willebrand'S Disease 2 Von Willebrand Disease Type Ii Von Willebrand Disease, Type Ii Vwd, Type 2 Von Willebrand Disease, Types 2a, 2b, 2m, And 2n Vwd Type 2 Von Willebrand Disease 2 Von Willebrand Disease Normandy Variant Von Willebrand Disease Type 2 Malmo Von Willebrand Disease Type I New York Von Willebrand Factor Deficiency Type 2 Vwd2a Vwd2b Vwd2m Vwd2n Von Willebrand Disease, Type 2a, 2b, 2m, And 2n Von Willebrand Disease, Type 2a Von Willebrand Disease, Type 2b Von Willebrand Disease, Type 2n
Suppurative Periapical Periodontitis	Periapical Abscess Apical Abscess Suppurative Apical Periodontitis Dentoalveolar Abscess Dental Abscess With Sinus Dentoalveolar Abscess With Sinus Dental Sinus Periapical Abscess Fistula Apical Tooth Abscess Apex Abscess Dental Abscess Nos Infection Of Tooth Nos Abscess Of Tooth Dental Infection Nos
Endocervical Carcinoma	Carcinoma Of Endocervix Carcinoma Of The Endocervix
Angiodysplasia	Angiodysplasia Of Colon Angiodysplasia Of Stomach And Duodenum With Hemorrhage Angiodysplasia Of Large Intestine Telangiectasia Of Colon Vascular Ectasia Of Colon Av - [Angiodysplasia Malformation Of Colon] Colon Angiodysplasia Colonic Angiodysplasia Vascular Ectasia Of Large Intestine
Sialuria	Sialuria, French Type French Type Sialuria Sialuria French Type Sialic Acid Storage Disease Sialic Acid Storage Disease, Finnish Type Infantile Sialic Acid Storage Disease
Congenital Disorder Of Glycosylation, Type Iic	CDG2C Congenital Disorder Of Glycosylation Type Iic Leukocyte Adhesion Deficiency Type Ii Cdg Iic Cdgiic Rambam-Hasharon Syndrome Leukocyte Adhesion Deficiency, Type Ii Lad2 Leukocyte Adhesion Deficiency 2 Cdg-Iic Congenital Disorder Of Glycosylation, Type 2c Rhs Cdg Syndrome Type Iic Lad-Ii Rambam Hasharon Syndrome Congenital Disorder Of Glycosylation 2c Glycosylation, Congenital Disorder Of, Type Iic
Pseudo-Von Willebrand Disease	Bdplt3 Von Willebrand Disease, Platelet-Type VWDP Platelet-Type Bleeding Disorder 3 Platelet Type-Von Willebrand Disease Pt-Vwd Von Willebrand Disease Platelet-Type Von Willebrand Disease, Platelet Type Pseudo Von Willebrand Disease Bleeding Disorder, Platelet-Type, 3 Pseudo-Von Willebrand Disease Type 2b Bleeding Disorder Platelet-Type 3 Pseudo-Vwd
Splenic Disease	Splenic Diseases Dyssplenism Spleen Disease Abnormality Of The Spleen Spleen Diseases
Factor Viii Deficiency	Autosomal Hemophilia A Hemophilia A Autosomal Factor Viii Deficiency Classic Hemophilia A Congenital Factor Viii Disorder Subhemophilia Factor 8 Deficiency, Congenital Factor Viii
Uterine Corpus Cancer	Corpus Uteri Cancer Malignant Uterine Corpus Neoplasm
Von Willebrand'S Disease	Von Willebrand Disease Von Willebrand Disorder Vascular Pseudohemophilia Hereditary Von Willebrand Disease Vwd Vascular Hemophilia Von Willebrand'S-Jurgens' Disease Von Willebrand-Jrgens Disease Von Willebrand Factor Deficiency Von Willebrand Factor, Deficiency Angiohemophilia Von Willebrand'S Factor Deficiency Von Willebrand Diseases Factor Viii Deficiency With Vascular Defect Vascular Haemophilia Willebrand Jurgen Thrombopathy Pseudohaemophilia Minot-Von Willebrand-Jurgen Disease Angiohaemophilia Angiohaemophilia A Angiohaemophilia B
Papillon-Lefevre Syndrome	Papillon-Lefevre Disease Papillon-Lefèvre Syndrome PLS Keratosis Palmoplantaris With Periodontopathia PALS Papillon Lefevre Syndrome Keratosis Palmoplantar-Periodontopathy Syndrome Papillon-Lefvre Syndrome Hyperkeratosis Palmoplantaris With Periodontosis Keratoris Palmoplantaris With Periodontopathia Keratosis Palmoplantar - Periodontopathy Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction Palmoplantar Keratoderma With Periodontosis Palsy
Autoimmune Polyendocrine Syndrome, Type Ii	Schmidt Syndrome Autoimmune Polyendocrine Syndrome Type 2 APS2 Autoimmune Polyglandular Syndrome Type 2 Diabetes Mellitus, Addison Disease, Myxedema Polyglandular Autoimmune Syndrome, Type Ii Pga Ii Polyendocrine Autoimmune Syndrome, Type Ii Aps Ii Autoimmune Polyglandular Syndrome Type Ii Diabetes Mellitus, Addison'S Disease, Myxedema Multiple Endocrine Deficiency Syndrome, Type 2 Pga 2 Pga-Ii Polyglandular Autoimmune Syndrome, Type 2 Polyglandular Deficiency Syndrome Type 2 Schmidt'S Syndrome Autoimmune Polyendocrinopathy Type 2 Aps Type 2 Autoimmune Thyroid Disease And/Or Type 1 Diabetes-Addison Disease Syndrome Autoimmune Syndrome Type Ii Polyglandular Autoimmune Syndrome Type Ii, Polyglandular
Endometrial Disease	Endometrial Disorder Endometrial Diseases
Coronavirus Infectious Disease
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Chromophobe Renal Cell Carcinoma	Chromophobe Adenocarcinoma Chromophobe Carcinoma Of Kidney Kidney Chromophobe Renal Cell Carcinoma, Chromophobe Cell Crcc Chrcc Chromophobe Renal Cell Adenocarcinoma Chromophobe Renal Carcinoma Chromophobe Carcinoma
Chromosomal Deletion Syndrome
Myopathy, Myofibrillar, 5	Myofibrillar Myopathy 5 MFM5 Myopathy, Myofibrillar, Filamin C-Related Filaminopathy, Autosomal Dominant Filaminopathy Muscle Filaminopathy Autosomal Dominant Filaminopathy Mfm Filamin C-Related Myopathy Myofibrillar Filamin C-Related Myopathy, Myofibrillar, Type 5
Marginal Zone B-Cell Lymphoma	Marginal Zone Lymphoma Mzl Mucosa-Associated Lymphoid Tissue Lymphoma
Primary Bacterial Infectious Disease
Pyoderma Gangrenosum	Phagedenic Pyoderma Phagedena Geometric
Autoimmune Disease Of Musculoskeletal System
Endocervical Adenocarcinoma	Endocervical Carcinoma
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Typhoid Fever	Typhoid Enteric Fever Typhoidal Salmonellosis Ileotyphus Infection By Salmonella Typhi Typhoid Any Site Typhoid Fever Any Site Typhoid Infection Typhoid Infection Any Site Typhoid Fever Confirmed Enteric Fever Nos
Middle Ear Disease	Middle Ear Anomaly Disorder Of Middle Ear
Endometritis
Intestinal Schistosomiasis	Schistosomiasis Japonica Schistosomiasis Mansoni Katayama Fever Schistosoma Japonicum Infection Schistosoma Mansoni Infectious Disease Schistosomiasis
Visceral Leishmaniasis	Kala-Azar Leishmaniasis, Visceral Infection By Visceral Leishmaniasis Leishmaniasis Visceral Sahib Disease Ponos Burdwan Fever Mard El Bicha Sirkari Disease Indian Visceral Leishmaniasis Dumdum Fever Visceral Leishmaniasis Due To Leishmania Donovani
Severe Covid-19
Ocular Melanoma	Intraocular Melanoma Uveal Melanoma Eye Melanoma Melanoma Of Eye Melanoma Of The Uvea Malignant Melanoma Of Eye
Aphthous Stomatitis	Oral Ulcer Canker Sore Aphtha Aphthous Ulceration Oral Aphthae Oral Aphthous Ulcer Canker Sores Stomatitis, Aphthous Minor Oral Aphthous Ulceration
Adrenal Cortical Hypofunction	Adrenal Cortical Insufficiency Corticoadrenal Insufficiency
Salivary Gland Disease	Salivary Gland Disorders Salivary Gland Diseases Non-Neoplastic Salivary Gland Disease Non-Neoplastic Salivary Gland Disorder Disorder Of Salivary Gland Lesion Of Salivary Gland Nos
Mouth Disease	Mouth Diseases Mouth Disorders
Rectum Adenocarcinoma	Rectal Adenocarcinoma Adenocarcinoma Of Rectum
Blood Coagulation Disease	Blood Coagulation Disorders Coagulation Protein Disease Inherited Blood Coagulation Disease Postpartum Coagulation Defect Postpartum Coagulation Defect With Delivery Coagulation Protein Disorders Puerperal Coagulopathy
Infective Endocarditis	Bacterial Endocarditis Endocarditis, Infective Infectious Endocarditis Endocarditis Infective
Ovarian Cystadenocarcinoma	Cystadenocarcinoma Of Ovary Cystadenocarcinoma Of The Ovary
Endocardium Disease
Immune System Disease	Abnormality Of The Immune System Immune System And Disorders Immune System Diseases
Suppression Of Tumorigenicity 12	Prostate Adenocarcinoma Adenocarcinoma Of Prostate ST12 Prostate Adenocarcinoma 1 Pac1
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm
Parasitic Helminthiasis Infectious Disease	Helminthiasis Intestinal Helminthiasis Helminth Infection Helminthosis Worm Infection Worm Infections Helminth Infections Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata Parasitic Enteritis Metazoal Dysentery Intestinal Worms Nos
Brain Glioma	Lower Grade Glioma Intracranial Glioma Glioma Nos
Ovarian Serous Cystadenocarcinoma	Serous Cystadenoma Cystadenoma Serous Cystadenoma, Serous
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Integumentary System Disease
Bone Inflammation Disease	Osteitis Bone Inflammatory Disease Inflammatory Disorder Of Bone
Ovary Adenocarcinoma	Ovarian Adenocarcinoma Adenocarcinoma Of The Ovary Ovarian Adenoacanthoma Adenocarcinoma Of Ovary
Respiratory System Disease	Abnormality Of The Respiratory System Respiration Disorders Respiratory Tract Diseases
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12903	SIGLEC5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27772	Siglec5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIGLEC5	MGD	MGI:2681107