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PIP4P1 - phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 Gene

Also Known as C14orf9; TMEM55B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 90809

About PIP4P1

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,457,681-20,461,434 (from NCBI)

This gene has 7 transcripts (splice variants), 259 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 22.8), thyroid (RPKM 17.4) and 25 other tissues.

Summary

TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

PIP4P1 Products (2)

mRNA	Protein	Name
NM_001100814.3	NP_001094284.1	type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1
NM_144568.4	NP_653169.2	type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	IDA IDA: Inferred from direct assay	16365287	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	29644770	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	25035345	GOA
involved in lysosome localization	IMP IMP: Inferred from mutant phenotype	29146937	GOA
involved in phosphatidylinositol dephosphorylation	IDA IDA: Inferred from direct assay	16365287	GOA
involved in positive regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	29644770	GOA
involved in response to sterol depletion	IDA IDA: Inferred from direct assay	25035345	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in late endosome membrane	IDA IDA: Inferred from direct assay	16365287	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	16365287	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIP4P1 Protein Structure

Tmemb_55A

0
100
200
277 a.a.

Protein Preferred Names	Protein Names
type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase	ptdIns-4,5-P(2) 4-phosphatase type I

PIP4P1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PIP4P1	Q86T03	RILPL1	Homo sapiens	Q5EBL4-3	Y2H Array	32296183
Intra	PIP4P1	Q86T03	RILPL1	Homo sapiens	Q5EBL4-3	Y2H Prey Pooling	32296183
Intra	PIP4P1	Q86T03	EPN2	Homo sapiens	O95208-2	Y2H Prey Pooling	32296183
Intra	PIP4P1	Q86T03	EPN2	Homo sapiens	O95208-2	Y2H Array	32296183
Intra	PIP4P1	Q86T03	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	PIP4P1	Q86T03	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	PIP4P1	Q86T03	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	PIP4P1	Q86T03	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	PIP4P1	Q86T03	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	PIP4P1	Q86T03	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	PIP4P1	Q86T03	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
Intra	PIP4P1	Q86T03	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	PIP4P1	Q86T03	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	PIP4P1	Q86T03	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	PIP4P1	Q86T03	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	PIP4P1	Q86T03	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	PIP4P1	Q86T03	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	PIP4P1	Q86T03	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 99	DFNB99 Autosomal Recessive Nonsyndromic Deafness 99 Autosomal Recessive Deafness 99 Deafness, Autosomal Recessive, 99
Lung Mucoepidermoid Carcinoma	Mucoepidermoid Carcinoma Of Lung
Congenital Disorder Of Glycosylation, Type Ip	CDG1P Congenital Disorder Of Glycosylation Ip Congenital Disorder Of Glycosylation 1p Alg11-Cdg Cdg-Ip Congenital Disorder Of Glycosylation Type Ip Cdg Syndrome Type Ip Carbohydrate Deficient Glycoprotein Syndrome Type Ip Congenital Disorder Of Glycosylation Type 1p Cdgip Cdg Ip Glycosylation, Congenital Disorder Of, Type Ip
Hermansky-Pudlak Syndrome 2	HPS2 Hermansky Pudlak Syndrome 2 Platelet Defects And Oculocutaneous Albinism Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Delta Storage Pool Disease Hermansky-Pudlak Syndrome, Type 2 Platelet Storage Pool Deficiency Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10565	PIP4P1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PIP4P1	MGD	MGI:2448501
Felis catus	PIP4P1	VGNC	VGNC:64183
Bos taurus	PIP4P1	VGNC	VGNC:32909
Rattus norvegicus	PIP4P1	RGD	RGD:1307475
Canis familiaris	PIP4P1	VGNC	VGNC:44573
Others	PIP4P1	NCBI