GRHPR - glyoxylate and hydroxypyruvate reductase Gene

Also Known as PH2; GLXR; GLYD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9380

About GRHPR

Cytogenetic location: 9p13.2 Genomic coordinates (GRCh38): 9:37,422,435-37,439,494 (from NCBI)

This gene has 12 transcripts (splice variants), 215 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 132.9), kidney (RPKM 67.4) and 24 other tissues.

Summary

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]

GRHPR Products (1)

mRNA	Protein	Name
NM_012203.2	NP_036335.1	glyoxylate reductase/hydroxypyruvate reductase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NADPH binding	IDA IDA: Inferred from direct assay	16756993	GOA
enables glyoxylate reductase (NADPH) activity	IDA IDA: Inferred from direct assay	10484776	GOA
enables hydroxypyruvate reductase (NADH) activity	IDA IDA: Inferred from direct assay	10484776	GOA
enables hydroxypyruvate reductase [NAD(P)H] activity	IDA IDA: Inferred from direct assay	10484776	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23599041	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16756993	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in glyoxylate metabolic process	IDA IDA: Inferred from direct assay	10484776	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of catalytic complex	IDA IDA: Inferred from direct assay	16756993	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRHPR Protein Structure

2-Hacid_dh

2-Hacid_dh_C

0
100
200
300
328 a.a.

Protein Preferred Names	Protein Names
glyoxylate reductase/hydroxypyruvate reductase	epididymis secretory sperm binding protein

GRHPR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GRHPR	Q9UBQ7	SLC23A1	Homo sapiens	Q9UHI7	Pull Down	23599041
Intra	GRHPR	Q9UBQ7	SLC23A1	Homo sapiens	Q9UHI7	Anti Tag CoIP	23599041
Intra	GRHPR	Q9UBQ7	SLC23A1	Homo sapiens	Q9UHI7	Gal4 VP16 Complement	23599041
Intra	GRHPR	Q9UBQ7	SLC23A1	Homo sapiens	Q9UHI7	Confocal	23599041
Intra	GRHPR	Q9UBQ7	SLC23A1	Homo sapiens	Q9UHI7	Y2H	23599041

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hyperoxaluria, Primary, Type Ii	Primary Hyperoxaluria Type 2 D-Glycerate Dehydrogenase Deficiency Glyoxylate Reductase/Hydroxypyruvate Reductase Deficiency HP2 Oxalosis Ii Glyceric Aciduria L-Glyceric Aciduria Primary Hyperoxaluria, Type Ii Oxalosis 2 Hyperoxaluria Primary 2 Hyperoxaluria Primary Type Ii Ph2 Primary Hyperoxaluria Type Ii
Primary Hyperoxaluria	Hyperoxaluria Hyperoxaluria, Primary Oxalosis Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I
Nephrocalcinosis	Hypercalcemic Nephropathy
Nephrolithiasis	Kidney Stones Stone - Kidney/Ureter Kidney Calculi
Nephrolithiasis, Calcium Oxalate	Kidney Stones Calculus Of Kidney Kidney Calculi Nephrolithiasis Renal Calculi Calcium Oxalate Urolithiasis CAON Urolithiasis, Calcium Oxalate Calcium Oxalate Nephrolithiasis Kidney Stone Nephrolith Renal Calculus Urinary Stones Renal Stone Calculus, Kidney Calculus, Renal Renal Lithiasis Renal Stones Urolithiasis Renal Calculus Or Stone Stone In Kidney Nephritic Calculus Multiple Kidney Calculi Multiple Kidney Calculus Nephrolithiasis Nos Pelvic Nephrolithiasis Pelviolithiasis Pelvis Nephrolithiasis
Hyperoxaluria, Primary, Type Iii	Primary Hyperoxaluria Type 3 HP3 Ph Iii Primary Hyperoxaluria Type Iii Hyperoxaluria Primary 3 Hyperoxaluria Non-Hp1/Non-Hp2 Hyperoxaluria Non-Ph I/Ph Ii Form Hyperoxaluria Primary Type Iii
Nephrolithiasis, Uric Acid	Nephrolithiasis, Uric Acid, Susceptibility To Uric Acid Urolithiasis Uric Acid Nephrolithiasis UAN Acute Urate Nephropathy Urolithiasis, Uric Acid Urolithiasis, Uric Acid, Susceptibility To Uric Acid Renal Calculus
Adenine Phosphoribosyltransferase Deficiency	Aprt Deficiency 2,8-Dihydroxyadenine Urolithiasis APRTD 2,8-Dihydroxyadeninuria Dihydroxyadeninuria Urolithiasis, 2,8-Dihydroxyadenine Urolithiasis, Dha Nephrolithiasis, Dha Dha Crystalline Nephropathy Nephrolithiasis Dha Urolithiasis Dha
End Stage Renal Disease	End Stage Renal Failure End-Stage Kidney Disease Kidney Failure, Chronic Chronic Kidney Disease Stage 5
D-Glyceric Aciduria	D-Glyceric Acidemia D-Glycericacidemia Glycerate Kinase Deficiency D-Glycerate Kinase Deficiency Non Ketotic Hyperglycinemia Syndrome Deficiency Of Glycerate Kinase Hyperglycinemia, Non-Ketotic D-GA
Urethral Calculus	Calculus In Urethra Urethral Stone Urethrolithiasis Urethra Calculi Impaction Urethra Calculus Impaction Urethra Stone Calculous Urethritis Urethral Calculi Impaction Urethral Calculus Impaction
Ureterolithiasis	Calculus Of Ureter Ureteric Stone Ureteral Calculi Ureteric Calculus Stone In The Ureter Ureter Calculi Ureteral Calculus Or Stone Ureterolith Ureterolithiasis Nos
Xanthinuria	Xanthine Dehydrogenase Deficiency Xanthine Oxidase Deficiency Hereditary Xanthinuria Xanthic Urolithiasis Xanthine Stone Disease Xanthinuria, Type I Combined Deficiency Of Xanthine Dehydrogenase And Aldehyde Oxidase Xdh Deficiency Classic Xanthinuria Xanthinuria, Type Ii Classical Xanthinuria Xanthine Calculus
Galloway-Mowat Syndrome 1	Galloway Syndrome Nephrosis-Neuronal Dysmigration Syndrome Nephrosis-Microcephaly Syndrome Camos Scar5 GAMOS1 Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Microcephaly, Hiatal Hernia And Nephrotic Syndrome Cerebellar Ataxia With Mental Retardation, Optic Atrophy, And Skin Abnormalities Spinocerebellar Ataxia, Autosomal Recessive 5, Formerly Scar5, Formerly Spinocerebellar Ataxia Autosomal Recessive 5 Cerebellar Ataxia With Intellectual Disability Optic Atrophy And Skin Abnormalities Camos Syndrome Cerebellar Ataxia-Intellectual Disability-Optic Atrophy-Skin Abnormalities Syndrome Galloway-Mowat Syndrome Spinocerebellar Ataxia, Autosomal Recessive, 5 Galloway Mowat Syndrome Spinocerebellar Ataxia, Autosomal Recessive 5
Purine-Pyrimidine Metabolic Disorder	Inborn Errors Of Purine-Pyrimidine Metabolism Disorder Of Purine Or Pyrimidine Metabolism
Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency	Favism Favism, Susceptibility To Hemolytic Anemia, G6pd Deficient Class I Glucose-6-Phosphate Dehydrogenase Deficiency Class I G6pd Deficiency Severe Hemolytic Anemia Due To G6pd Deficiency Anemia, Non-Spherocytic Hemolytic, Due To G6pd Deficiency NSHA G6pd Deficient Hemolytic Anemia
Cystinuria	CSNU Cystinuria Type B Cystinuria Type A Cystinuria, Type I, Formerly Csnu1, Formerly Cystinuria, Type Ii, Formerly Cystinuria, Type Iii, Formerly Csnu3, Formerly Cystinuria, Type Non-I, Formerly Cystinuria-Lysinuria Cystinuria-Lysinuria Syndrome Csnu1 Csnu3 Cystinuria 1 Cystinuria Type A/B Cystinuria Type I Cystinuria Type Ii Cystinuria Type Iii Cystinuria Type Non-I Cystinuria, Type A/B Cystinuria Type 1 Cystinuria - Lysinuria Csnu - [Cystinuria] Cystine Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-142035	N-Propargylglycine		99.70%	Unkown
HY-RS05790	GRHPR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18067	Grhpr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24542	Grhpr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GRHPR	RGD	RGD:1308851
Canis familiaris	GRHPR	VGNC	VGNC:41479
Bos taurus	GRHPR	VGNC	VGNC:29637
Mus musculus	GRHPR	MGD	MGI:1923488
Felis catus	GRHPR	VGNC	VGNC:67460
Macaca mulatta	GRHPR	VGNC	VGNC:103270
Others	GRHPR	NCBI