GRHPR - glyoxylate and hydroxypyruvate reductase Gene

Homo sapiens

Also known as PH2; GLXR; GLYD

Gene ID: 9380 | Gene type: protein coding

About GRHPR

Cytogenetic location: 9p13.2 Genomic coordinates (GRCh38): 9:37,422,435-37,439,494 (from NCBI)

This gene has 12 transcripts (splice variants), 215 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 132.9), kidney (RPKM 67.4) and 24 other tissues.

Summary

This gene encodes an Enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The Enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]

GRHPR Products(1)

mRNA	Protein	Name
NM_012203.2	NP_036335.1	glyoxylate reductase/hydroxypyruvate reductase

GRHPR Protein Structure

2-Hacid_dh

2-Hacid_dh_C

0
100
200
300
328 a.a.

Protein Preferred Names

Protein Names

glyoxylate reductase/hydroxypyruvate reductase

epididymis secretory sperm binding protein

Related Diseases

Diseases

Alias

Hyperoxaluria, Primary, Type Ii

Primary Hyperoxaluria Type 2	D-Glycerate Dehydrogenase Deficiency
Glyoxylate Reductase/Hydroxypyruvate Reductase Deficiency	HP2
Oxalosis Ii	Glyceric Aciduria
L-Glyceric Aciduria	Primary Hyperoxaluria, Type Ii
Oxalosis 2	Hyperoxaluria Primary 2
Hyperoxaluria Primary Type Ii	Ph2
Primary Hyperoxaluria Type Ii

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Nephrocalcinosis

Hypercalcemic Nephropathy

Nephrolithiasis

Kidney Stones	Stone - Kidney/Ureter
Kidney Calculi

Nephrolithiasis, Calcium Oxalate

Kidney Stones	Calculus Of Kidney
Kidney Calculi	Nephrolithiasis
Renal Calculi	Calcium Oxalate Urolithiasis
CAON	Urolithiasis, Calcium Oxalate
Calcium Oxalate Nephrolithiasis	Kidney Stone
Nephrolith	Renal Calculus
Urinary Stones	Renal Stone
Calculus, Kidney	Calculus, Renal
Renal Lithiasis	Renal Stones
Urolithiasis	Renal Calculus Or Stone
Stone In Kidney	Nephritic Calculus
Multiple Kidney Calculi	Multiple Kidney Calculus
Nephrolithiasis Nos	Pelvic Nephrolithiasis
Pelviolithiasis	Pelvis Nephrolithiasis

Hyperoxaluria, Primary, Type Iii

Primary Hyperoxaluria Type 3	HP3
Ph Iii	Primary Hyperoxaluria Type Iii
Hyperoxaluria Primary 3	Hyperoxaluria Non-Hp1/Non-Hp2
Hyperoxaluria Non-Ph I/Ph Ii Form	Hyperoxaluria Primary Type Iii

Nephrolithiasis, Uric Acid

Nephrolithiasis, Uric Acid, Susceptibility To	Uric Acid Urolithiasis
Uric Acid Nephrolithiasis	UAN
Acute Urate Nephropathy	Urolithiasis, Uric Acid
Urolithiasis, Uric Acid, Susceptibility To	Uric Acid Renal Calculus

Adenine Phosphoribosyltransferase Deficiency

Aprt Deficiency	2,8-Dihydroxyadenine Urolithiasis
APRTD	2,8-Dihydroxyadeninuria
Dihydroxyadeninuria	Urolithiasis, 2,8-Dihydroxyadenine
Urolithiasis, Dha	Nephrolithiasis, Dha
Dha Crystalline Nephropathy	Nephrolithiasis Dha
Urolithiasis Dha

End Stage Renal Disease

End Stage Renal Failure	End-Stage Kidney Disease
Kidney Failure, Chronic	Chronic Kidney Disease Stage 5

D-Glyceric Aciduria

D-Glyceric Acidemia	D-Glycericacidemia
Glycerate Kinase Deficiency	D-Glycerate Kinase Deficiency
Non Ketotic Hyperglycinemia Syndrome	Deficiency Of Glycerate Kinase
Hyperglycinemia, Non-Ketotic	D-GA

Urethral Calculus

Calculus In Urethra	Urethral Stone
Urethrolithiasis	Urethra Calculi Impaction
Urethra Calculus Impaction	Urethra Stone
Calculous Urethritis	Urethral Calculi Impaction
Urethral Calculus Impaction

Ureterolithiasis

Calculus Of Ureter	Ureteric Stone
Ureteral Calculi	Ureteric Calculus
Stone In The Ureter	Ureter Calculi
Ureteral Calculus Or Stone	Ureterolith
Ureterolithiasis Nos

Xanthinuria

Xanthine Dehydrogenase Deficiency	Xanthine Oxidase Deficiency
Hereditary Xanthinuria	Xanthic Urolithiasis
Xanthine Stone Disease	Xanthinuria, Type I
Combined Deficiency Of Xanthine Dehydrogenase And Aldehyde Oxidase	Xdh Deficiency
Classic Xanthinuria	Xanthinuria, Type Ii
Classical Xanthinuria	Xanthine Calculus

Galloway-Mowat Syndrome 1

Galloway Syndrome	Nephrosis-Neuronal Dysmigration Syndrome
Nephrosis-Microcephaly Syndrome	Camos
Scar5	GAMOS1
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Microcephaly, Hiatal Hernia And Nephrotic Syndrome
Cerebellar Ataxia With Mental Retardation, Optic Atrophy, And Skin Abnormalities	Spinocerebellar Ataxia, Autosomal Recessive 5, Formerly
Scar5, Formerly	Spinocerebellar Ataxia Autosomal Recessive 5
Cerebellar Ataxia With Intellectual Disability Optic Atrophy And Skin Abnormalities	Camos Syndrome
Cerebellar Ataxia-Intellectual Disability-Optic Atrophy-Skin Abnormalities Syndrome	Galloway-Mowat Syndrome
Spinocerebellar Ataxia, Autosomal Recessive, 5	Galloway Mowat Syndrome
Spinocerebellar Ataxia, Autosomal Recessive 5

Purine-Pyrimidine Metabolic Disorder

Inborn Errors Of Purine-Pyrimidine Metabolism

Disorder Of Purine Or Pyrimidine Metabolism

Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency

Favism	Favism, Susceptibility To
Hemolytic Anemia, G6pd Deficient	Class I Glucose-6-Phosphate Dehydrogenase Deficiency
Class I G6pd Deficiency	Severe Hemolytic Anemia Due To G6pd Deficiency
Anemia, Non-Spherocytic Hemolytic, Due To G6pd Deficiency	NSHA
G6pd Deficient Hemolytic Anemia

Cystinuria

CSNU	Cystinuria Type B
Cystinuria Type A	Cystinuria, Type I, Formerly
Csnu1, Formerly	Cystinuria, Type Ii, Formerly
Cystinuria, Type Iii, Formerly	Csnu3, Formerly
Cystinuria, Type Non-I, Formerly	Cystinuria-Lysinuria
Cystinuria-Lysinuria Syndrome	Csnu1
Csnu3	Cystinuria 1
Cystinuria Type A/B	Cystinuria Type I
Cystinuria Type Ii	Cystinuria Type Iii
Cystinuria Type Non-I	Cystinuria, Type A/B
Cystinuria Type 1	Cystinuria - Lysinuria
Csnu - [Cystinuria]	Cystine Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05790	GRHPR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GRHPR	RGD	RGD:1308851
Canis familiaris	GRHPR	VGNC	VGNC:41479
Bos taurus	GRHPR	VGNC	VGNC:29637
Mus musculus	GRHPR	MGD	MGI:1923488
Felis catus	GRHPR	VGNC	VGNC:67460
Macaca mulatta	GRHPR	VGNC	VGNC:103270
Others	GRHPR	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.