Tnfrsf21 - tumor necrosis factor receptor superfamily, member 21 Gene

Also Known as DR6; TR7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 94185

Summary

Involved in several processes, including negative regulation of cytokine production; negative regulation of lymphocyte proliferation; and oligodendrocyte apoptotic process. Located in axon. Is intrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; lung; metanephros; nervous system; and nose. Orthologous to human TNFRSF21 (TNF Receptor Superfamily member 21). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf21 Products (1)

mRNA Protein Name
NM_178589.3 NP_848704.1 tumor necrosis factor receptor superfamily member 21 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in B cell apoptotic process IMP
IMP: Inferred from mutant phenotype
12515813 MGI
involved in T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11485735 MGI
involved in adaptive immune response IMP
IMP: Inferred from mutant phenotype
11485735 MGI
involved in humoral immune response IMP
IMP: Inferred from mutant phenotype
11485735 MGI
involved in myelination IMP
IMP: Inferred from mutant phenotype
21725297 MGI
involved in negative regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
12515813 MGI
involved in negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
11485735 MGI
involved in negative regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
11485735 MGI
involved in negative regulation of interleukin-13 production IMP
IMP: Inferred from mutant phenotype
11485735 MGI
involved in negative regulation of interleukin-5 production IMP
IMP: Inferred from mutant phenotype
11485735 MGI
involved in neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
23559013 MGI
involved in oligodendrocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
21725297 MGI
involved in regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
21725297 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
12515813 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 21

  • Death receptor 6

  • TNFR-related death receptor-6

Recombinant Tnfrsf21 Proteins

Cat. No. Product Name Accession Purity
HY-P72664 DR6/TNFRSF21 Protein, Mouse (HEK293, Fc-His) Q9EPU5 (Q42-H349) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75278 DR6/TNFRSF21 Protein, Mouse (HEK293, His) Q9EPU5 (Q42-H349) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15594A Phen-DC3 Trifluoromethanesulfonate 98.64% Unkown
HY-RS14812 TNFRSF21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18109 Tnfrsf21 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24583 Tnfrsf21 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15594 Phen-DC3 / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990526 Anti-TNFRSF21/DR6/CD358 Antibody Inhibitor 98.58% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf21 NCBI NCBI:27242