Robo4 - roundabout guidance receptor 4 Gene

Also Known as 1200012D01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74144

Summary

Enables signaling receptor activity. Acts upstream of or within negative regulation of cell migration. Located in external side of plasma membrane. Is expressed in several structures, including forebrain; genitourinary system; neural retina; submandibular gland; and vascular system. Human ortholog(s) of this gene implicated in aortic valve disease 3. Orthologous to human ROBO4 (roundabout guidance receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Robo4 Products (2)

mRNA Protein Name
NM_001309390.2 NP_001296319.2 roundabout homolog 4 isoform 1 precursor
NM_028783.4 NP_083059.3 roundabout homolog 4 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12941633 MGI
enables signaling receptor activity IDA
IDA: Inferred from direct assay
12941633 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of blood vessel endothelial cell migration IDA
IDA: Inferred from direct assay
12941633 MGI
acts upstream of or within negative regulation of blood vessel endothelial cell migration IDA
IDA: Inferred from direct assay
12941633 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12941633 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

roundabout homolog 4

  • Magic roundabout

Recombinant Robo4 Proteins

Cat. No. Product Name Accession Purity
HY-P78031 ROBO4 Protein, Mouse (HEK293, His) Q8C310-1 (L28-W480) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12113 ROBO4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18406 Robo4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24887 Robo4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992299 Anti-Robo4 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Robo4 NCBI NCBI:54538