ROBO4 - roundabout guidance receptor 4 Gene
Also Known as MRB; AOVD3; ECSM4
Species: Homo sapiens
About ROBO4
This gene has 10 transcripts (splice variants), 99 orthologues, 36 paralogues and is associated with 2 phenotypes. Broad expression in fat (RPKM 35.9), spleen (RPKM 32.4) and 17 other tissues.
Summary
Predicted to enable cell-cell adhesion mediator activity. Involved in angiogenesis and establishment of endothelial barrier. Located in extracellular exosome. Implicated in aortic valve disease 3. [provided by Alliance of Genome Resources, Apr 2022]
ROBO4 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001301088.2 | NP_001288017.1 | roundabout homolog 4 isoform 2 |
| NM_019055.6 | NP_061928.4 | roundabout homolog 4 isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in establishment of endothelial barrier |
IMP
IMP: Inferred from mutant phenotype
|
30455415 | GOA |
ROBO4 Protein Structure
I-set: Immunoglobulin I-set domain (32 - 124)
I-set: Immunoglobulin I-set domain (138 - 220)
fn3: Fibronectin type III domain (350 - 432)
- 0
- 200
- 400
- 600
- 800
- 1007 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
roundabout homolog 4 |
|
ROBO4 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ROBO4 | Q8WZ75 | CEP19 | Homo sapiens | Q96LK0 | 32296183 |
Recombinant ROBO4 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P71262 | ROBO4 Protein, Human (HEK293, Fc) | Q8WZ75-1 (Q28-R467) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P76009 | ROBO4 Protein, Human (HEK293, His) | Q8WZ75-1 (Q28-R467) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Aortic Valve Disease 3 |
|
|
| Aortic Valve Disease 1 |
|
|
| Diaphragmatic Hernia, Congenital |
|
|
| Aortic Aneurysm |
|
|
| Aortic Aneurysm, Familial Thoracic 1 |
|
|
| Corneal Neovascularization |
|
|
| Hypoplastic Left Heart Syndrome |
|
|
| Megalencephalic Leukoencephalopathy With Subcortical Cysts 2a |
|
|
| Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b |
|
|
| Hantavirus Pulmonary Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | ROBO4 | VGNC | VGNC:34081 |
| Rattus norvegicus | ROBO4 | RGD | RGD:6494870 |
| Mus musculus | ROBO4 | MGD | MGI:1921394 |
| Canis familiaris | ROBO4 | VGNC | VGNC:45687 |
| Macaca mulatta | ROBO4 | VGNC | VGNC:76760 |
| Felis catus | ROBO4 | VGNC | VGNC:81954 |
| Others | ROBO4 | NCBI |