ROBO4 - roundabout guidance receptor 4 Gene

Also Known as MRB; AOVD3; ECSM4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54538

About ROBO4

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:124,883,691-124,897,865 (from NCBI)

This gene has 10 transcripts (splice variants), 99 orthologues, 36 paralogues and is associated with 2 phenotypes. Broad expression in fat (RPKM 35.9), spleen (RPKM 32.4) and 17 other tissues.

Summary

Predicted to enable cell-cell adhesion mediator activity. Involved in angiogenesis and establishment of endothelial barrier. Located in extracellular exosome. Implicated in aortic valve disease 3. [provided by Alliance of Genome Resources, Apr 2022]

ROBO4 Products (2)

mRNA Protein Name
NM_001301088.2 NP_001288017.1 roundabout homolog 4 isoform 2
NM_019055.6 NP_061928.4 roundabout homolog 4 isoform 1 precursor
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in establishment of endothelial barrier IMP
IMP: Inferred from mutant phenotype
30455415 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ROBO4 Protein Structure

I-set

I-set: Immunoglobulin I-set domain (32 - 124)

I-set

I-set: Immunoglobulin I-set domain (138 - 220)

fn3

fn3: Fibronectin type III domain (350 - 432)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1007 a.a.
Protein Preferred Names Protein Names

roundabout homolog 4

  • roundabout homolog 4, magic roundabout

ROBO4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ROBO4 Q8WZ75 CEP19 Homo sapiens Q96LK0 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ROBO4 Proteins

Cat. No. Product Name Accession Purity
HY-P71262 ROBO4 Protein, Human (HEK293, Fc) Q8WZ75-1 (Q28-R467) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76009 ROBO4 Protein, Human (HEK293, His) Q8WZ75-1 (Q28-R467) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Aortic Valve Disease 3
  • AOVD3

Aortic Valve Disease 1
  • Aortic Valve Disease

  • Bicuspid Aortic Valve

  • Aortic Valve Disorder

  • AOVD1

  • Bav

  • Bicuspid Aortic Valve Disease

  • Familial Bicuspid Aortic Valve

  • Aortic Valve Calcification

  • Aovd

  • Aortic Valve, Bicuspid

  • Aortic Valve, Calcification Of

  • Aortic Stenosis, Calcific

  • Familial Bav

  • Calcific Aortic Stenosis

  • Calcification Of Aortic Valve

  • Abnormality Of The Aortic Valve

  • Aortic Valve Disease, Type 1

  • Aortic Valve Disease 2

  • Bicommissural Aortic Valve

Diaphragmatic Hernia, Congenital
  • Congenital Diaphragmatic Hernia

  • Diaphragmatic Hernia

  • Cdh

  • Congenital Diaphragmatic Defect

  • Hernia, Diaphragmatic

  • Dih

  • Hernia, Congenital Diaphragmatic

  • Hcd

  • Diaphragmatic Defect, Congenital

  • Diaphragm, Unilateral Agenesis Of

  • Hemidiaphragm, Agenesis Of

  • Diaphragmatic Hernia 1

  • Agenesis Of Hemidiaphragm

  • Unilateral Agenesis Of Diaphragm

  • Hernia Diaphragmatic

  • Hernia Diaphragmatic Congenital

  • Hernia, Diaphragmatic, Type 1

  • Hiatus Hernia

  • Oesophageal Hiatus Hernia

  • Paraoesophageal Hernia

  • Sliding Hiatus Hernia

  • Congenital Diaphragm Hernia

  • Congenital Diaphragm Defect With Hernia

  • Gross Congenital Diaphragm Defect

Aortic Aneurysm
  • Aortic Rupture

  • Thoracoabdominal Aortic Aneurysm, Ruptured

  • Ruptured Aortic Aneurysm

  • Aortic Aneurysms

  • Aortic Aneurysm Without Mention Of Rupture Nos

  • Ruptured Abdominal Aortic Aneurysm

  • Aortic Aneurysm, Ruptured

  • Ruptured Thoracic Aortic Aneurysm

Aortic Aneurysm, Familial Thoracic 1
  • Thoracic Aortic Aneurysm

  • Annuloaortic Ectasia

  • Familial Thoracic Aortic Aneurysm And Aortic Dissection

  • Familial Aortic Dissection

  • Familial Taad

  • Familial Thoracic Aortic Aneurysm

  • Congenital Aneurysm Of Ascending Aorta

  • Familial Aortic Aneurysm

  • Familial Thoracic Aortic Aneurysm And Dissection

  • Aortic Aneurysm, Thoracic

  • AAT1

  • Faa1

  • Aortic Dissection, Familial

  • Aortic Aneurysm, Familial Thoracic

  • Aneurysm, Thoracic Aortic

  • Faa

  • Ftaad

  • Taa

  • Taad

  • Cystic Medial Necrosis Of Aorta

  • Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

  • Aortic Aneurysm Thoracic

  • Familial Aortic Aneurysms

  • Aneurysm, Aortic, Thoracic, Familial, Type 1

  • Aneurysm Of Thoracic Aorta

  • Intrathoracic Aneurysm

  • Thoracic Aorta Aneurysm

  • Thoracic Aortic Aneurysm Without Rupture

  • Thoracic Aneurysm

  • Thorax Arterial Aneurysm

  • Thoracic Artery Aneurysm

  • Thoracic Arterial Aneurysm

  • Thorax Aneurysm

  • Thorax Aortic Aneurysm

  • Dissection Of Thoracic Aorta

Corneal Neovascularization
  • Corneal Neovascularisation

  • Corneal Vascularisation

  • Extensive Superficial Corneal Vascularisation

Hypoplastic Left Heart Syndrome
  • Hlhs

  • Heart, Hypoplastic Left, Syndrome

  • Hypoplasia Of The Left Heart

  • Left Heart Hypoplasia Syndrome

  • Hlhs - [Hypoplastic Left Heart Syndrome]

  • Hypoplasia Of Aortic Valve, In Hypoplastic Left Heart Syndrome

  • Atresia Of Mitral Valve, In Hypoplastic Left Heart Syndrome

  • Atresia Or Marked Hypoplasia Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle

  • Atresia Or Marked Hypoplasia, Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle With Mitral Valve Atresia

  • Aortic Valve Atresia, In Hypoplastic Left Heart Syndrome

  • Ascending Aorta Hypoplasia, In Hypoplastic Left Heart Syndrome

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2a
  • MLC2A

  • Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 2a

  • Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 2a

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b
  • Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b, Remitting, With Or Without Mental Retardation

Hantavirus Pulmonary Syndrome
  • Hps

  • Four Corners Hantavirus

  • Hards

  • Hantavirus

  • Hantavirus-Associated Respiratory Distress Syndrome

  • Hanta Virus

  • Hantavirus Cardiopulmonary Syndrome

  • Hps - [Hantavirus Pulmonary Syndrome]

  • Hcps - [Hantavirus Cardiopulmonary Syndrome]

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus ROBO4 VGNC VGNC:34081
Rattus norvegicus ROBO4 RGD RGD:6494870
Mus musculus ROBO4 MGD MGI:1921394
Canis familiaris ROBO4 VGNC VGNC:45687
Macaca mulatta ROBO4 VGNC VGNC:76760
Felis catus ROBO4 VGNC VGNC:81954
Others ROBO4 NCBI