ROBO4 Protein, Human (HEK293, His)
Based on 1 Customer Validation
ROBO4 protein is a receptor for Slit proteins (especially SLIT2) and plays a crucial regulatory role in angiogenesis and blood vessel patterning. It mediates the inhibition of primary endothelial cell migration by Slit protein and helps regulate the angiogenic process. ROBO4 Protein, Human (HEK293, His) is the recombinant human-derived ROBO4 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
ROBO4 protein is a receptor for Slit proteins (especially SLIT2) and plays a crucial regulatory role in angiogenesis and blood vessel patterning. It mediates the inhibition of primary endothelial cell migration by Slit protein and helps regulate the angiogenic process. ROBO4 Protein, Human (HEK293, His) is the recombinant human-derived ROBO4 protein, expressed by HEK293 , with C-His labeled tag.
Background
The ROBO4 Protein functions as a receptor for Slit proteins, particularly SLIT2, and appears to play a crucial role in angiogenesis and vascular patterning. It is implicated in mediating the inhibition of primary endothelial cell migration by Slit proteins, contributing to the regulation of cellular responses during angiogenic processes. Furthermore, ROBO4 is involved in maintaining the organization and function of the endothelial barrier, as evidenced by its role in endothelial barrier organization and function. The protein interacts with SLIT2 and ENAH, underscoring its specific engagement with key ligands and associated proteins in the regulation of vascular development and endothelial cell behavior.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-His
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Accession
Q8WZ75-1 (Q28-R467)
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Molecular Construction
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N-term
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ROBO4 (Q48-E469)
Accession # Q8WZ75-1 -
His
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C-term
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Protein Length
Partial
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Synonyms
ROBO4; FLJ20798; Roundabout Guidance Receptor 4; Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila); Roundabout Homolog 4; Roundabout, Axon Guidance Receptor, Homolog 4; ECSM4; Roundabout Homolog 4, Magic Roundabout; MRB; Roundabout Homolog 4 (Drosophila); Magic Roundabout; AOVD3
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AA Sequence
QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIATHMPGSYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKR
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Predicted Molecular Mass
49 kDa
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Molecular Weight
Approximately 65-80 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (237 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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