FY-21
FY-21 is a selective inhibitor of LSD1 (IC50=340 nM), with anti-proliferation and anti-colony formation activities. FY-21 enhances p53 expression, down-regulates HOXA9 and MEIS1 expression. FY-21 also induces leukemia cell differentiation to exhibts antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 3049681-20-8
- Formula: C17H15F3N2O6
- Molecular Weight:400.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 340 nM (LSD1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
83 μM
Compound: 3k; FY-21
|
Cytotoxicity against human MOLM-13 cells incubated for 7 days by CCK8 assay
Cytotoxicity against human MOLM-13 cells incubated for 7 days by CCK8 assay
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[PMID: 37257211] |
| MV4-11 | IC50 |
42 μM
Compound: 3k; FY-21
|
Cytotoxicity against human MV4-11 cells incubated for 7 days by CCK8 assay
Cytotoxicity against human MV4-11 cells incubated for 7 days by CCK8 assay
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[PMID: 37257211] |
Chemical Information
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CAS No. 3049681-20-8
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Molecular Weight 400.31
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Formula C17H15F3N2O6
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SMILES
OC1=C(C=C2C(NCCC2=C1)C3=CC=C(C=C3)[N+]([O-])=O)O.FC(C(O)=O)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FY-21 Related Classifications
HY-155526 Related Classifications
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