3049681-20-8
3049681-20-8
Chemical Structure
FY-21
- CAS No.: 3049681-20-8
- Formula:C17H15F3N2O6
- Molecular Weight:400.31
InChIKey: TUBPMNKNZANWJC-UHFFFAOYSA-N
SMILES: OC1=C(C=C2C(NCCC2=C1)C3=CC=C(C=C3)[N+]([O-])=O)O.FC(C(O)=O)(F)F
Biological Activity: FY-21 is a selective inhibitor of LSD1 (IC50=340 nM), with anti-proliferation and anti-colony formation activities. FY-21 enhances p53 expression, down-regulates HOXA9 and MEIS1 expression. FY-21 also induces leukemia cell differentiation to exhibts antitumor activity[1].
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FY-21 | FY-21 is a selective inhibitor of LSD1 (IC50=340 nM), with anti-proliferation and anti-colony formation activities. FY-21 enhances p53 expression, down-regulates HOXA9 and MEIS1 expression. FY-21 also induces leukemia cell differentiation to exhibts antitumor activity. | |||||||||||||||||||||
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References
Keywords
