Ccn2 - cellular communication network factor 2 Gene

Also Known as Ctgf; Hcs24; Fisp12; fisp-12

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14219

Summary

Enables heparin binding activity and Integrin binding activity. Acts upstream of or within several processes, including cartilage condensation; cell surface receptor signaling pathway; and chondrocyte proliferation. Located in extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Orthologous to human CCN2 (cellular communication network factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ccn2 Products (1)

mRNA Protein Name
NM_010217.2 NP_034347.2 CCN family member 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparin binding IDA
IDA: Inferred from direct assay
9184077 MGI
enables integrin binding IDA
IDA: Inferred from direct assay
10446209 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IDA
IDA: Inferred from direct assay
10082563 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
12736220 MGI
acts upstream of or within cartilage condensation IDA
IDA: Inferred from direct assay
15305294 MGI
acts upstream of or within cell migration IDA
IDA: Inferred from direct assay
10082563 MGI
acts upstream of or within cell-matrix adhesion IDA
IDA: Inferred from direct assay
9184077 MGI
acts upstream of or within chondrocyte differentiation IDA
IDA: Inferred from direct assay
15305294 MGI
acts upstream of or within chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
18597638 MGI
acts upstream of or within connective tissue development IMP
IMP: Inferred from mutant phenotype
23839921 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
9184077 MGI
acts upstream of or within integrin-mediated signaling pathway IDA
IDA: Inferred from direct assay
10082563 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
18213577 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18597638 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
11237711 MGI
acts upstream of or within reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
19364818 MGI
acts upstream of or within regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
18597638 MGI
acts upstream of or within tissue homeostasis IMP
IMP: Inferred from mutant phenotype
23839921 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
9184077 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
1888698 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CCN family member 2

  • Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)

  • cellular communication network factor 1

  • fibroblast inducible secreated protein

  • fibroblast inducible secreted protein

  • hypertrophic chondro

Recombinant Ccn2 Proteins

Cat. No. Product Name Accession Purity
HY-P72154 CCN2/CTGF Protein, Mouse (GST) P29268 (Q26-Y344) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-167201 2ccPA Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5314 OK2 Inhibitor 99.13% Unkown
HY-RS02111 CCN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181537 PROTAC TEAD1/IAP degrader-2 / Unkown
HY-184179 TEAD degrader-1 Degrader / Unkown
HY-184366 2C-CN hydrochloride Agonist / Unkown
HY-RS17160 Ccn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23610 Ccn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccn2 NCBI NCBI:1490