Htr6 - 5-hydroxytryptamine (serotonin) receptor 6 Gene

Also Known as 5-HT6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15565

About Htr6

Chromosome 4: 138,788,419-138,802,881 reverse strand.GRCm39:CM000997.3

This gene has 2 transcripts (splice variants), 114 orthologues, 9 paralogues and is associated with 7 phenotypes. Biased expression in cortex adult (RPKM 1.8), frontal lobe adult (RPKM 1.5) and 11 other tissues.

Summary

Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Involved in cerebral cortex cell migration and positive regulation of TOR signaling. Located in cilium. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; and cortical plate. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human HTR6 (5-hydroxytryptamine receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Htr6 Products (2)

mRNA Protein Name
NM_001377096.1 NP_001364025.1 5-hydroxytryptamine receptor 6
NM_021358.2 NP_067333.1 5-hydroxytryptamine receptor 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled serotonin receptor activity IDA
IDA: Inferred from direct assay
11406289 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23027611 MGI
Biological Process GO Annotation Evidence References Source
involved in cerebral cortex cell migration IMP
IMP: Inferred from mutant phenotype
25078650 MGI
involved in positive regulation of TOR signaling IDA
IDA: Inferred from direct assay
23027611 MGI
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
22179047 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Htr6 Protein Structure

7tmA_5-HT6

7tmA_5-HT6: cd15054 (28 - 53)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (28 - 332)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (60 - 86)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (98 - 128)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (140 - 163)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (184 - 213)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (262 - 292)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (300 - 325)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 6

  • 5-HT-6

  • serotonin receptor 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06480 HTR6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06481 Htr6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06482 Htr6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htr6 NCBI NCBI:3362