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Cat. No.: HY-P11784

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p5RHH

p5RHH is an acid-activated membrane-lytic peptide derived from melittin. p5RHH, as a siRNA delivery vector, initiates synchronous disassembly of nanocomplexes and endosome lysis in response to acidic pH, and triggers the release of siRNA into the cytoplasm following macropinocytosis.

For research use only. We do not sell to patients.

CAS No.: 1423724-82-6
Formula: C₁₁₂H₁₈₉N₄₁O₂₅S
Molecular Weight:2542.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

p5RHH Chemical Structure

CAS No.: 1423724-82-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 1423724-82-6
Molecular Weight 2542.02
Formula C₁₁₂H₁₈₉N₄₁O₂₅S
Sequence

Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Arg-Arg-Arg-His-Arg-Arg-His-Cys
Sequence Shortening

VLTTGLPALISWIRRRHRRHC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hou KK, et al. Mechanisms of nanoparticle-mediated siRNA transfection by melittin-derived peptides. ACS Nano. 2013;7(10):8605-8615. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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