1. Anti-infection
    Metabolic Enzyme/Protease
  2. HCV
    HCV Protease
  3. IDX184

IDX184 

Cat. No.: HY-19558
Handling Instructions

IDX184 is a potent and orally bioavailable inhibitor of HCV replication. IDX184 potently inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM).

For research use only. We do not sell to patients.

IDX184 Chemical Structure

IDX184 Chemical Structure

CAS No. : 1036915-08-8

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Description

IDX184 is a potent and orally bioavailable inhibitor of HCV replication. IDX184 potently inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM)[1][2].

IC50 & Target

IC50: 0.31 μM (HCV polymerase)[2]
Ki: 52.3 nM (HCV polymerase)[2]

In Vitro

IDX184 is a liver-targeted prodrug of the nucleotide 2′-MeG-MP. IDX184 is a liver-targeted nucleotide polymerase inhibitor of hepatitis C virus[1].
IDX184 is a second generation, orally bioavailable nucleotide prodrug designed to provide increased anti-HCV efficacy and safety versus the parent nucleoside. In HCV replicon testing, IDX184 is the most potent inhibitor (EC50=0.3-0.45 μM) compared to any of the 2’ or 4’ modified nucleosides (EC50=4-6 μM) and is also highly inhibitory in the JFH-1 infectious system (EC50=0.06-0.11 μM). IDX184 is not toxic (CC50>100μM) in any tested cell line[2].

Molecular Weight

626.62

Formula

C₂₅H₃₅N₆O₉PS

CAS No.

1036915-08-8

SMILES

C[[email protected]]([[email protected]](O[[email protected]@H]1CO[P](NCC2=CC=CC=C2)(OCCSC(C(C)(C)CO)=O)=O)([H])N3C(NC(N)=NC4=O)=C4N=C3)([[email protected]@H]1O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

IDX184IDX 184IDX-184HCVHCV ProteaseHepatitis C virusreplicationJFH-1infectiousInhibitorinhibitorinhibit

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