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Cat. No.: HY-106884

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Cyrtominetin

Cyrtominetin is a RANKL inhibitor with favorable ADMET properties. Cyrtominetin competitively blocks the binding of RANKL-RANK and increases the compactness of RANKL. Cyrtominetin can be used in studies related to osteoporosis.

For research use only. We do not sell to patients.

CAS No.: 519-55-1
Formula: C₁₇H₁₆O₆
Molecular Weight:316.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cyrtominetin Chemical Structure

CAS No.: 519-55-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

In Vitro

Cyrtominetin (100 ns) forms a complex with human RANKL that exhibits stable conformational dynamics over 100 ns of simulation, with an average backbone C_α-RMSD of 2.86 Å, increased compactness, stabilized active-site residues, and persistent hydrogen bonding interactions^[1].
Cyrtominetin (60-80 ns) binds to human RANKL with a highly favorable total binding free energy of -50.205 kJ/mol, stabilized by a combination of electrostatic and van der Waals interactions with specific active-site residues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 519-55-1
Molecular Weight 316.31
Formula C₁₇H₁₆O₆
SMILES

OC1=C2C(O[C@@H](CC2=O)C3=CC(O)=C(O)C=C3)=C(C)C(O)=C1C
Structure Classification
- Flavonoids
- Flavonols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang X, et al. Computational exploration of Eucommia ulmoides flavonoids as potential RANKL inhibitors via molecular docking and dynamics simulations. Scientific reports. 2025 May 17;15(1):17175. [Content Brief]

[2]. Zhang X, et al. Computational study of flavonoids from Eucommia ulmoides against RANKL-induced osteoclastogenesis using Molecular Docking and molecular dynamics simulation[J]. 2025.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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