GBP5 - guanylate binding protein 5 Gene

Also Known as GBP-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115362

About GBP5

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,256,189-89,272,860 (from NCBI)

This gene has 5 transcripts (splice variants), 98 orthologues and 10 paralogues. Biased expression in appendix (RPKM 33.2), lymph node (RPKM 19.8) and 11 other tissues.

Summary

This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

GBP5 Products (3)

mRNA Protein Name
NM_001134486.4 NP_001127958.1 guanylate-binding protein 5 isoform 1
NM_001391920.1 NP_001378849.1 guanylate-binding protein 5 isoform 2
NM_052942.5 NP_443174.1 guanylate-binding protein 5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
26996307 GOA
enables endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
31091448 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables molecular function inhibitor activity IDA
IDA: Inferred from direct assay
31091448 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21151871 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
21151871 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
17266443 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
26996307 GOA
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
22461501 GOA
involved in positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
22461501 GOA
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
22461501 GOA
involved in protein localization to Golgi apparatus IDA
IDA: Inferred from direct assay
21151871 GOA
Cellular Component GO Annotation Evidence References Source
is active in Golgi apparatus IDA
IDA: Inferred from direct assay
26996307 GOA
located in Golgi apparatus IDA
IDA: Inferred from direct assay
17266443 GOA
is active in Golgi membrane IDA
IDA: Inferred from direct assay
31091448 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17266443 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
21151871 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GBP5 Protein Structure

GBP

GBP: Guanylate-binding protein, N-terminal domain (18 - 280)

GBP_C

GBP_C: Guanylate-binding protein, C-terminal domain (282 - 573)

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  • 200
  • 300
  • 400
  • 500
  • 586 a.a.
Protein Preferred Names Protein Names

guanylate-binding protein 5

  • GBP-TA antigen

GBP5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GBP5 Q96PP8 GBP4 Homo sapiens Q96PP9
Anti Tag CoIP
21151871
Intra
GBP5 Q96PP8 GBP4 Homo sapiens Q96PP9
BiFC
21151871
Intra
GBP5 Q96PP8 GBP3 Homo sapiens Q9H0R5
BiFC
21151871
Intra
GBP5 Q96PP8 GBP3 Homo sapiens Q9H0R5
Anti Tag CoIP
21151871
Intra
GBP5 Q96PP8 GBP1 Homo sapiens P32455
BiFC
21151871
Intra
GBP5 Q96PP8 GBP1 Homo sapiens P32455
Anti Tag CoIP
21151871
Intra
GBP5 Q96PP8 GBP1 Homo sapiens P32455
Anti Tag CoIP
33961781
Intra
GBP5 Q96PP8 GBP1 Homo sapiens P32455
Anti Tag CoIP
28514442
Intra
GBP5 Q96PP8 GBP2 Homo sapiens P32456
BiFC
21151871
Intra
GBP5 Q96PP8 GBP2 Homo sapiens P32456
Anti Tag CoIP
21151871
Intra
GBP5 Q96PP8 GBP5 Homo sapiens Q96PP8
GMS
20180847
Intra
GBP5 Q96PP8 GBP5 Homo sapiens Q96PP8
BiFC
21151871
Intra
GBP5 Q96PP8 ACSM1 Homo sapiens Q08AH1
Anti Tag CoIP
33961781
Intra
GBP5 Q96PP8 APOL2 Homo sapiens Q9BQE5
Anti Tag CoIP
33961781
Intra
GBP5 Q96PP8 GBP5 Homo sapiens Q96PP8
Y2H Pooling
16189514
Intra
GBP5 Q96PP8 ACSM1 Homo sapiens Q08AH1
Anti Tag CoIP
28514442
Intra
GBP5 Q96PP8 APOL2 Homo sapiens Q9BQE5
Anti Tag CoIP
28514442
Intra
GBP5 Q96PP8 GBP5 Homo sapiens Q96PP8
Anti Tag CoIP
21151871
Intra
GBP5 Q96PP8 GBP5 Homo sapiens Q96PP8
Y2H
21151871
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05311 GBP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18761 Gbp5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25248 Gbp5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GBP5 RGD RGD:1311040
Mus musculus GBP5 MGD MGI:2429943
Bos taurus GBP5 VGNC VGNC:59183
Others GBP5 NCBI