GBP4 - guanylate binding protein 4 Gene

Also Known as Mpa2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115361

About GBP4

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,181,144-89,198,942 (from NCBI)

This gene has 3 transcripts (splice variants), 83 orthologues and 10 paralogues. Broad expression in lung (RPKM 16.3), lymph node (RPKM 13.8) and 23 other tissues.

Summary

Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]

GBP4 Products (1)

mRNA Protein Name
NM_052941.5 NP_443173.2 guanylate-binding protein 4

GBP4 Protein Structure

GBP

GBP: Guanylate-binding protein, N-terminal domain (33 - 296)

GBP_C

GBP_C: Guanylate-binding protein, C-terminal domain (298 - 594)

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  • 640 a.a.
Protein Preferred Names Protein Names

guanylate-binding protein 4

  • GBP-4

GBP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GBP4 Q96PP9 PNPT1 Homo sapiens Q8TCS8
Crosslink
30021884
Intra
GBP4 Q96PP9 GBP4 Homo sapiens Q96PP9
Y2H
21151871
Intra
GBP4 Q96PP9 GBP4 Homo sapiens Q96PP9
Anti Tag CoIP
21151871
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
High Pressure Neurological Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05310 GBP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18935 Gbp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22180 Gbp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25425 Gbp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GBP4 RGD RGD:1310579
Mus musculus GBP4 MGD MGI:1926263
Others GBP4 NCBI