DCAF11 - DDB1 and CUL4 associated factor 11 Gene

Also Known as GL014; WDR23; PRO2389

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80344

About DCAF11

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,114,777-24,125,242 (from NCBI)

This gene has 38 transcripts (splice variants), 1 gene allele and 188 orthologues. Ubiquitous expression in liver (RPKM 25.7), small intestine (RPKM 25.5) and 25 other tissues.

Summary

This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 Ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

DCAF11 Products (3)

mRNA	Protein	Name
NM_001163484.2	NP_001156956.1	DDB1- and CUL4-associated factor 11 isoform 1
NM_025230.5	NP_079506.3	DDB1- and CUL4-associated factor 11 isoform 1
NM_181357.2	NP_852002.1	DDB1- and CUL4-associated factor 11 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16949367	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cul4-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16949367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCAF11 Protein Structure

WD40

0
100
200
300
400
500
546 a.a.

Protein Preferred Names	Protein Names
DDB1- and CUL4-associated factor 11	WD repeat domain 23

DCAF11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DCAF11	Q8TEB1	GPSM1	Homo sapiens	Q86YR5-3	Y2H Array	32296183
Intra	DCAF11	Q8TEB1	GPSM1	Homo sapiens	Q86YR5-3	Y2H Prey Pooling	32296183
Intra	DCAF11	Q8TEB1	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	28514442
Intra	DCAF11	Q8TEB1	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	33961781
Intra	DCAF11	Q8TEB1	DDB1	Homo sapiens	Q16531	Pull Down	19109893
Intra	DCAF11	Q8TEB1	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	DCAF11	Q8TEB1	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	DCAF11	Q8TEB1	TNNI1	Homo sapiens	P19237	Y2H Array	32296183
Intra	DCAF11	Q8TEB1	TNNI1	Homo sapiens	P19237	Y2H Prey Pooling	32296183
Intra	DCAF11	Q8TEB1	TNNI2	Homo sapiens	P48788	Y2H Prey Pooling	32296183
Intra	DCAF11	Q8TEB1	TNNI2	Homo sapiens	P48788	Y2H Array	32296183
Intra	DCAF11	Q8TEB1	RCN1	Homo sapiens	Q15293	Y2H Prey Pooling	32296183
Intra	DCAF11	Q8TEB1	RCN1	Homo sapiens	Q15293	Y2H Array	32296183
Cross	DCAF11	Q8TEB1	vif	Human immunodeficiency virus	P12504	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Loeys-Dietz Syndrome 1	Furlong Syndrome Loeys-Dietz Aortic Aneurysm Syndrome LDS1 Aat5 Loeys-Dietz Syndrome Type 1 Aortic Aneurysm, Familial Thoracic 5 Familial Throacic Aortic Aneurysm 5 Loeys-Dietz Syndrome Aortic Aneurysm Syndrome, Loeys-Dietz Type Familial Thoracic Aortic Aneurysm 5 Ldas Marfanoid Disorder-Craniosynostosis Syndrome Aneurysm, Aortic, Thoracic, Familial, Type 5 Loeys-Dietz Syndrome, Type 1 Loeys-Dietz Syndrome, Type 2a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W288798	DCAF11 ligand 2		/	Unkown
HY-159076	E3 ligase Ligand 7		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DCAF11	VGNC	VGNC:97258
Felis catus	DCAF11	VGNC	VGNC:80991
Mus musculus	DCAF11	MGD	MGI:90168
Rattus norvegicus	DCAF11	RGD	RGD:1311288
Macaca mulatta	DCAF11	VGNC	VGNC:84330
Canis familiaris	DCAF11	VGNC	VGNC:57371
Others	DCAF11	NCBI