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Cat. No.: HY-N10446

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Maydispenoid B

Maydispenoid B is a potent immunosuppressor. Maydispenoid B can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation.

For research use only. We do not sell to patients.

CAS No.: 3024647-69-3
Formula: C₂₅H₃₄O₄
Molecular Weight:398.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Maydispenoid B Chemical Structure

CAS No.: 3024647-69-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Maydispenoid B is a potent immunosuppressor. Maydispenoid B can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	10 μM Compound: 2; DRB	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 33074690]

In Vitro

Maydispenoid B (compound 3) exhibits potential inhibitory activity in anti-CD3/anti-CD28 monoclonal antibodies (mAbs) stimulated murine splenocytes proliferation, with an IC₅₀ value of 9.38 μM, respectively^[1].
Maydispenoid B suppresses the murine splenocytes proliferation activated by lipopolysaccharide (LPS), with an IC₅₀ value of 16.82 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3024647-69-3
Molecular Weight 398.54
Formula C₂₅H₃₄O₄
SMILES

CC1=CC(/C2=C(C(C[C@]3([C@@]4([C@@H](C)C[C@H](/C=C(C)/C)O4)CC[C@@]3(C[C@]12[H])C)[H])=O)\CO)=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Microorganisms
Bipolaris maydis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Duan X, et al. New secondary metabolites with immunosuppressive activity from the phytopathogenic fungus Bipolaris maydis. Bioorg Chem. 2020 Jun;99:103816. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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