Isolation and identification of dihydroartemisinic acid from artemisia annua and its possible role in the biosynthesis of artemisinin

  • J Nat Prod. 1999 Mar;62(3):430-3. doi: 10.1021/np980370p.
TE Wallaart  1 ,  van Uden W ,  HG Lubberink ,  HJ Woerdenbag ,  N Pras ,  WJ Quax
Affiliations
  • 1. Department of Pharmaceutical Biology, University Centre for Pharmacy, Groningen Institute for Drug Studies, University of Groningen, A. Deusinglaan 1, NL-9713 AV Groningen, The Netherlands.
PMID: 10096851 DOI: 10.1021/np980370p
Abstract

Dihydroartemisinic acid (2) was isolated as a natural product from Artemisia annua in a 66% yield, and its structure was confirmed by 1H and 13C NMR spectroscopy. Compound 2 could be chemically converted to artemisinin (4) under conditions that may also be present in the living plant. The results suggest that the conversion of 2 into 4 in the living plant might be a nonenzymatic conversion.

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