MRPL18 - mitochondrial ribosomal protein L18 Gene

Also Known as L18mt; HSPC071; MRP-L18

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29074

About MRPL18

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:159,789,812-159,798,429 (from NCBI)

This gene has 4 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 18.5), colon (RPKM 17.9) and 25 other tissues.

Summary

This nuclear gene encodes a protein component of the larger 39S subunit of mitochondrial ribosome. This protein may also aid in the import of nuclear-encoded 5S rRNA into mitochondria. Alternative splicing results in multiple transcript variants, most of which are not predicted to encode a protein. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Jan 2016]

MRPL18 Products (2)

mRNA Protein Name
NM_001318817.2 NP_001305746.1 39S ribosomal protein L18, mitochondrial isoform 2
NM_014161.5 NP_054880.2 39S ribosomal protein L18, mitochondrial isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5S rRNA binding IDA
IDA: Inferred from direct assay
21685364 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in rRNA import into mitochondrion IDA
IDA: Inferred from direct assay
21685364 GOA
Cellular Component GO Annotation Evidence References Source
part of mitochondrial large ribosomal subunit IDA
IDA: Inferred from direct assay
25278503 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
28892042 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRPL18 Protein Structure

Ribosomal_L18p

Ribosomal_L18p: Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast (79 - 146)

  • 0
  • 100
  • 180 a.a.
Protein Preferred Names Protein Names

39S ribosomal protein L18, mitochondrial

  • mitochondrial large ribosomal subunit protein uL18m

MRPL18 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MRPL18 Q9H0U6 LAPTM5 Homo sapiens Q13571
Y2H Prey Pooling
32296183
Intra
MRPL18 Q9H0U6 LAPTM5 Homo sapiens Q13571
Y2H Array
32296183
Intra
MRPL18 Q9H0U6 MRPL38 Homo sapiens Q96DV4
Y2H Prey Pooling
32296183
Intra
MRPL18 Q9H0U6 MRPL38 Homo sapiens Q96DV4
Anti Tag CoIP
33961781
Intra
MRPL18 Q9H0U6 MRPL38 Homo sapiens Q96DV4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08665 MRPL18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MRPL18 VGNC VGNC:31621
Mus musculus MRPL18 MGD MGI:1914931
Canis familiaris MRPL18 VGNC VGNC:43382
Felis catus MRPL18 VGNC VGNC:63596
Rattus norvegicus MRPL18 RGD RGD:1306387
Others MRPL18 NCBI