ENPP7 - ectonucleotide pyrophosphatase/phosphodiesterase 7 Gene

Also Known as NPP7; NPP-7; E-NPP 7; ALK-SMase

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 339221

About ENPP7

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:79,730,943-79,742,219 (from NCBI)

This gene has 2 transcripts (splice variants), 273 orthologues and 6 paralogues. Biased expression in small intestine (RPKM 36.1), duodenum (RPKM 15.1) and 1 other tissue.

Summary

The protein encoded by this gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity. [provided by RefSeq, Oct 2016]

ENPP7 Products (1)

mRNA Protein Name
NM_178543.5 NP_848638.3 ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphoric diester hydrolase activity IDA
IDA: Inferred from direct assay
16255717 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sphingomyelin phosphodiesterase activity IDA
IDA: Inferred from direct assay
12671034 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
28292932 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA replication IDA
IDA: Inferred from direct assay
12671034 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12671034 GOA
involved in sphingomyelin metabolic process IDA
IDA: Inferred from direct assay
12671034 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
12671034 GOA
located in microvillus IDA
IDA: Inferred from direct assay
12671034 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
15205117 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENPP7 Protein Structure

Phosphodiest

Phosphodiest: Type I phosphodiesterase / nucleotide pyrophosphatase (33 - 356)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
Protein Preferred Names Protein Names

ectonucleotide pyrophosphatase/phosphodiesterase family member 7

  • alkaline sphingomyelin phosphodiesterase

ENPP7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ENPP7 Q6UWV6 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
ENPP7 Q6UWV6 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
ENPP7 Q6UWV6 LRRC73 Homo sapiens Q5JTD7
Y2H Array
32296183
Intra
ENPP7 Q6UWV6 LRRC73 Homo sapiens Q5JTD7
Y2H Prey Pooling
32296183
Intra
ENPP7 Q6UWV6 BACH2 Homo sapiens Q9BYV9
Validated Y2H
32296183
Intra
ENPP7 Q6UWV6 BACH2 Homo sapiens Q9BYV9
Y2H Prey Pooling
32296183
Intra
ENPP7 Q6UWV6 BACH2 Homo sapiens Q9BYV9
Y2H Array
32296183
Intra
ENPP7 Q6UWV6 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
ENPP7 Q6UWV6 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
ENPP7 Q6UWV6 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
ENPP7 Q6UWV6 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ENPP7 Proteins

Cat. No. Product Name Accession Purity
HY-P77358 ENPP-7 Protein, Human (HEK293, His) Q6UWV6 (A22-S439) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Familial Adenomatous Polyposis

  • Adenomatous Polyposis Coli

  • Fap

  • Familial Polyposis Coli

  • Familial Multiple Polyposis Syndrome

  • Adenomatous Polyposis Of The Colon

  • Familial Intestinal Polyposis

  • Fpc

  • Familial Adenomatous Polyposis Of The Colon

  • Familial Multiple Polyposis

  • Familial Polyposis Of The Colon

  • Hereditary Polyposis Coli

  • Polyposis, Adenomatous Intestinal

  • Adenomatous Familial Polyposis

  • Adenomatous Familial Polyposis Syndrome

  • Myh-Associated Polyposis

  • Colorectal Adenomatous Polyposis

  • Adenomatous Polyposis, Familial

  • Mutyh-Associate Polyposis
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04393 ENPP7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ENPP7 VGNC VGNC:82476
Bos taurus ENPP7 VGNC VGNC:55820
Mus musculus ENPP7 MGD MGI:3027917
Canis familiaris ENPP7 VGNC VGNC:40378
Rattus norvegicus ENPP7 RGD RGD:1359324
Macaca mulatta ENPP7 VGNC VGNC:72090
Others ENPP7 NCBI