MN1 - MN1 proto-oncogene, transcriptional regulator Gene

Also Known as MGCR; MGCR1; CEBALID; MGCR1-PEN; dJ353E16.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4330

About MN1

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:27,748,277-27,801,756 (from NCBI)

This gene has 4 transcripts (splice variants), 184 orthologues and is associated with 83 phenotypes. Ubiquitous expression in brain (RPKM 2.3), esophagus (RPKM 2.2) and 21 other tissues.

Summary

Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]

MN1 Products (1)

mRNA	Protein	Name
NM_002430.3	NP_002421.3	transcriptional activator MN1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	31839203	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of osteoblast proliferation	IDA IDA: Inferred from direct assay	15890672	GOA
involved in positive regulation of vitamin D receptor signaling pathway	IDA IDA: Inferred from direct assay	15890672	GOA
involved in regulation of cell cycle G1/S phase transition	IDA IDA: Inferred from direct assay	15890672	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	31839203	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcriptional activator MN1	meningioma (disrupted in balanced translocation) 1

Related Diseases

Diseases	Alias
Cebalid Syndrome	Mn1 C-Terminal Truncation Syndrome CEBALID Craniofacial Defects, Dysmorphic Ears, Structural Brain Abnormalities, Expressive Language Delay, And Impaired Intellectual Development Mctt Mctt Syndrome Mn1 C-Terminal Truncation Syndrome
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Rhombencephalosynapsis
Chordoma	CHDM Notochordoma Notochordal Sarcoma Chordoma, Susceptibility To Chordocarcinoma Chordoepithelioma
Astroblastoma	Cerebral Astroblastoma
Cns Neuroblastoma With Foxr2 Activation	Central Nervous System Neuroblastoma With Foxr2 Activation Cns Nb-Foxr2 Cns Neuroblastoma, Foxr2-Activated
Central Nervous System Neuroblastoma
Astroblastoma, Mn1-Altered	Cns High-Grade Neuroepithelial Tumors With Mn1 Alteration
Central Nervous System Germ Cell Tumor	Central Nervous System Germ Cell Tumour Germ Cell Tumor Of The Cns Germ Cell Tumour Of The Cns
Anaplastic Pleomorphic Xanthoastrocytoma
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Supratentorial Ependymoma
High Grade Ependymoma	Ependymal Neoplasm Ependymal Tumors Malignant Ependymoma Ependymal Tumor Anaplastic Ependymoma Experimental Organism Malignant Ependymoma Ependymoma Of Brain
Childhood Infratentorial Ependymoma	Pediatric Infratentorial Ependymoma
Anaplastic Ependymoma	Ependymoma, Anaplastic Undifferentiated Ependymoma
Rela Fusion-Positive Ependymoma	Supratentorial C11orf95-Rela Fused Ependymoma C11orf95 Fusion-Positive Supratentorial Ependymoma
Chondroid Lipoma
Pleomorphic Xanthoastrocytoma	Pxa Pleomorphic Xantho-Astrocytoma
Polymicrogyria	Pmg
Cerebral Ventricle Cancer	Cerebral Ventricle Neoplasms Cerebral Ventricle Neoplasm Intraventricular Tumor Of Brain
Supratentorial Cancer	Supratentorial Neoplasms Brain Neoplasm, Supratentorial Malignant Supratentorial Tumor Cancer, Supratentorial
Cerebrum Cancer	Cerebral Cancer Neoplasm Of Cerebrum Tumor Of Cerebrum Malignant Neoplasm Of Cerebrum
Myxopapillary Ependymoma	Ependymoma Myxopapillary
Large Congenital Melanocytic Nevus	Giant Pigmented Hairy Nevus Giant Congenital Melanocytic Nevus Gmn Congenital Pigmented Nevus Lcmn Gphn Giant Congenital Nevus Bathing Trunk Nevus Congenital Giant Pigmented Nevus Congenital Hairy Nevus Giant Hairy Nevus Giant Pigmented Nevus Congenital Giant Pigmented Nevus Of Skin Congenital Melanocytic Nevus Syndrome Giant Congenital Melanocytic Nevi Giant Congenital Pigmented Nevus Melanocytic Nevus Syndrome, Congenital
Pineal Gland Cancer	Tumor Of The Pineal Region Malignant Pineal Region Tumor Malignant Tumor Of Pineal Gland Neoplasm Of Pineal Gland Neoplasm Of The Pineal Region Pineal Body Neoplasm Pineocytic Tumor Malignant Neoplasm Of Pineal Gland Pineal Gland Neoplasm Pineocytoma
Tanycytic Ependymoma
Chordoid Glioma	Chordoid Glioma Of The Third Ventricle
Embryonal Tumor With Multilayered Rosettes, C19mc-Altered	Ependymoblastoma
Gaucher Disease, Type Ii	GD2 Gd Ii Gaucher Disease, Acute Neuronopathic Type Gaucher Disease Type 2 Gaucher Disease Type Ii Gaucher'S Disease Type Ii Infantile Cerebral Gaucher Disease Acute Neuronopathic Gaucher Disease Gd 2 Gaucher Disease, Infantile Cerebral Gaucher Disease 2 Type 2 Gaucher Disease Gaucher Disease, Type 2
Solitary Fibrous Tumor/Hemangiopericytoma	Sft/Hpc
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-D3243	Mn1		/	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99584	Suvizumab	Inhibitor	≥99.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19378	MIV-150	Inhibitor	/	Unkown
HY-RS08565	MN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19865	Mn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26364	Mn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MN1	VGNC	VGNC:107802
Rattus norvegicus	MN1	RGD	RGD:1565571
Bos taurus	MN1	VGNC	VGNC:31536
Canis familiaris	MN1	VGNC	VGNC:52951
Mus musculus	MN1	MGD	MGI:1261813
Others	MN1	NCBI