1. Anti-infection
  2. HIV

MIV-150 (Synonyms: PC 815)

Cat. No.: HY-19378
Handling Instructions

MIV-150 is a nonnucleoside reverse transcriptase (NNRT) inhibitor, blocking HIV-1 and HIV-2 infections, with an EC50<1 nM against HIV-1/HIV-2MN.

For research use only. We do not sell to patients.

MIV-150 Chemical Structure

MIV-150 Chemical Structure

CAS No. : 231957-54-3

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

MIV-150 is a nonnucleoside reverse transcriptase (NNRT) inhibitor, blocking HIV-1 and HIV-2 infections, with an EC50<1 nM against HIV-1/HIV-2MN.

IC50 & Target[1]

HIV-1

<1 nM (EC50)

HIV-2

<1 nM (EC50)

In Vitro

The activity of MIV-150 to protect target cells from infection is assayed using a syncytial assay. The EC50 of MIV-150 against HIV-1MN in CEM.SS cells is below 1 nM. These data are in agreement with the findings of Medivir. MIV-150 effectively inactivated free virus with an EC50 of 0.004 μg/mL (or 0.01 μM). It is demonstrated MIV-150 is highly effective against HIV and that the drug blocks viruses that are resistant to other marketed HIV antiretrovirals such as Nevirapine, Delavirdine, and Efavirenz. In addition, resistance to MIV-150 develops more slowly than to other anti-HIV drugs tested. For example, in vitro studies demonstrate that resistance development in the presence of nevirapine and delavirdine takes only 4 to 5 weeks compared with 45 weeks in the presence of MIV-150[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7147 mL 13.5737 mL 27.1474 mL
5 mM 0.5429 mL 2.7147 mL 5.4295 mL
10 mM 0.2715 mL 1.3574 mL 2.7147 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

368.36

Formula

C₁₉H₁₇FN₄O₃

CAS No.

231957-54-3

SMILES

O=C(N[[email protected]@H]1[[email protected]](C2=C(F)C=CC(C(CC)=O)=C2O)C1)NC3=NC=C(C#N)C=C3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
MIV-150
Cat. No.:
HY-19378
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MIV-150

Cat. No.: HY-19378