MIV-150
MIV-150 is a nonnucleoside reverse transcriptase (NNRT) inhibitor, blocking HIV-1 and HIV-2 infections, with an EC50<1 nM against HIV-1/HIV-2MN.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 231957-54-3
- Formel: C19H17FN4O3
- Molecular Weight:368.36
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-10570
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LersivirineNNRTI -
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IslatravirNucleoside Reverse Transcriptase Translocation Inhibitor -
HY-90005R
Etravirine (Standard) -
HY-10574R
Rilpivirine (Standard)NNRTI -
HY-104012R
Islatravir (Standard)Reference Standard
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
HIV-1 <1 nM (EC50) |
HIV-2 <1 nM (EC50) |
In Vitro
The activity of MIV-150 to protect target cells from infection is assayed using a syncytial assay. The EC50 of MIV-150 against HIV-1MN in CEM.SS cells is below 1 nM. These data are in agreement with the findings of Medivir. MIV-150 effectively inactivated free virus with an EC50 of 0.004 μg/mL (or 0.01 μM). It is demonstrated MIV-150 is highly effective against HIV and that the drug blocks viruses that are resistant to other marketed HIV antiretrovirals such as Nevirapine, Delavirdine, and Efavirenz. In addition, resistance to MIV-150 develops more slowly than to other anti-HIV drugs tested. For example, in vitro studies demonstrate that resistance development in the presence of nevirapine and delavirdine takes only 4 to 5 weeks compared with 45 weeks in the presence of MIV-150[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 231957-54-3
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Molecular Weight 368.36
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Formel C19H17FN4O3
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SMILES
O=C(N[C@@H]1[C@H](C2=C(F)C=CC(C(CC)=O)=C2O)C1)NC3=NC=C(C#N)C=C3
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Synonyms
PC 815
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MIV-150 Related Classifications
HY-19378 Related Classifications
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