Carrageenan/MIV-150 (PC-815), a combination microbicide

  • Sex Transm Dis. 2007 Jan;34(1):9-14. doi: 10.1097/01.olq.0000223287.46097.4b.
José A Fernández-Romero  1 ,  Mitchell Thorn ,  Stuart G Turville ,  Kanani Titchen ,  Kristin Sudol ,  Jifan Li ,  Todd Miller ,  Melissa Robbiani ,  Robin A Maguire ,  Robert W Buckheit Jr ,  Tracy L Hartman ,  David M Phillips
Affiliations
  • 1. Population Council, New York, NY, USA.
PMID: 16924181 DOI: 10.1097/01.olq.0000223287.46097.4b
Abstract

Objective: The objective of this article is to study the effect of PC-815, a novel combination microbicide containing carrageenan and the nonnucleoside Reverse Transcriptase Inhibitor (NNRTI) MIV-150, in blocking HIV-1 and HIV-2 infections in vitro as compared with Carraguard alone.

Goal: The goal of this study was to develop a combination microbicide that is more efficacious than Carraguard against HIV-1 and HIV-2.

Study design: The microtiter syncytial assay was used to evaluate: 1) the Antiviral and virucidal activity of MIV-150 against HIV-1MN; 2) the additive effect of MIV-150 when combined with carrageenan; and 3) a possible interference of seminal fluid in the Antiviral activity of these compounds.

Results: MIV-150 effectively inactivated free virus. Combination of MIV-150 and Carraguard demonstrated an additive Antiviral effect. Seminal fluid had no effect on the Antiviral activity of MIV-150 or Carraguard. The average concentration that blocks 50% of Infection (EC50) for PC-815 was approximately 10 times stronger than Carraguard for the different clinical isolates used in the study.

Conclusion: Theoretically, PC-815 is likely to be a more efficacious microbicide than Carraguard.

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