HCy-Lyso
HCy-Lyso is a lysosome-targeting turn-on fluorescent probe based on hydrocyanine. HCy-Lyso integrates a hydrocyanine moiety for selective recognition of hydroxyl radicals (•OH) and a morpholine group for lysosome targeting. Upon reacting with •OH, HCy-Lyso undergoes an extension of its π-conjugation system, producing a strong fluorescence signal at 598 nm when excited at 510 nm.
For research use only. We do not sell to patients.
- Formula: C24H30N2O
- Molecular Weight:362.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
In the absence of •OH, the fluorescence intensity of HCy-Lyso is minimal due to limited π conjugation and coplanarity. Once oxidized, both the nitrogen and morpholine moieties in the hydrocyanine are protonated. These protonated amines are membrane-impermeable in lysosomes, resulting in the selective encapsulation of HCy-Lyso in lysosomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 362.51
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Formula C24H30N2O
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SMILES
CC1(C(N(C2=CC=CC=C12)CC)/C=C/C3=CC=C(N4CCOCC4)C=C3)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ransdell-Green EC, et al. Advances in Fluorescence Techniques for the Detection of Hydroxyl Radicals near DNA and Within Organelles and Membranes. Antioxidants (Basel). 2025 Jan 10;14(1):79. [Content Brief]
[2]. Zhong L, et al. Rational design of a lysosome-targeted fluorescent probe for monitoring the generation of hydroxyl radicals in ferroptosis pathways. RSC Adv. 2024 Apr 22;14(18):12864-12872. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HCy-Lyso Related Classifications
HY-172333 Related Classifications
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