Chymase-IN-1
Based on 1 Customer Validation
Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.17%
- CAS 番号: 862090-74-2
- 分子式: C20H15ClNO4PS
- 分子量:431.83
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 29 nM (chymase)[1]
Chymase-IN-1 (compound 5f) is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. Results demonstrate that Chymase-IN-1 has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 862090-74-2
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性状 Solid
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分子量 431.83
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分子式 C20H15ClNO4PS
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Color White to off-white
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SMILES
O=C(NC1=CC=C2C=CC=CC2=C1)C(P(O)(O)=O)C3=CSC4=CC=C(Cl)C=C43
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 50 mg/mL (115.79 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3157 mL | 11.5786 mL | 23.1573 mL | 57.8932 mL |
| 5 mM | 0.4631 mL | 2.3157 mL | 4.6315 mL | 11.5786 mL | |
| 10 mM | 0.2316 mL | 1.1579 mL | 2.3157 mL | 5.7893 mL | |
| 15 mM | 0.1544 mL | 0.7719 mL | 1.5438 mL | 3.8595 mL | |
| 20 mM | 0.1158 mL | 0.5789 mL | 1.1579 mL | 2.8947 mL | |
| 25 mM | 0.0926 mL | 0.4631 mL | 0.9263 mL | 2.3157 mL | |
| 30 mM | 0.0772 mL | 0.3860 mL | 0.7719 mL | 1.9298 mL | |
| 40 mM | 0.0579 mL | 0.2895 mL | 0.5789 mL | 1.4473 mL | |
| 50 mM | 0.0463 mL | 0.2316 mL | 0.4631 mL | 1.1579 mL | |
| 60 mM | 0.0386 mL | 0.1930 mL | 0.3860 mL | 0.9649 mL | |
| 80 mM | 0.0289 mL | 0.1447 mL | 0.2895 mL | 0.7237 mL | |
| 100 mM | 0.0232 mL | 0.1158 mL | 0.2316 mL | 0.5789 mL |
Chymase-IN-1 関連分類
HY-100269 関連分類
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