FGFR4-IN-1
Based on 1 publication(s) in Google Scholar
FGFR4-IN-1 (example 98) is a potent inhibitor of FGFR4 with IC50 of 0.4 nM.
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- 純度: 99.43%
- CAS 番号: 1708971-72-5
- 分子式: C24H27N7O5
- 分子量:493.52
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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溶剤 & 溶解度
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MedChemExpress（MCE）の使用を引用している文献 FGFR4-IN-1
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生物活性
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FGFR4 0.7 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hep 3B2 | IC50 |
8.9 nM
Compound: 6a
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Antiproliferative activity against human Hep3B cells with high FGFR4 expression assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method
Antiproliferative activity against human Hep3B cells with high FGFR4 expression assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method
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[PMID: 30987781] |
| Huh-7 | IC50 |
17.3 nM
Compound: 6a
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Antiproliferative activity against human HuH7 cells with high FGFR4 expression assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method
Antiproliferative activity against human HuH7 cells with high FGFR4 expression assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method
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[PMID: 30987781] |
| Huh-7 | IC50 |
25 nM
Compound: 69
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Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by cell proliferation assay
Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by cell proliferation assay
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[PMID: 32930584] |
| SK-HEP1 | IC50 |
>10000 nM
Compound: 6a
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Antiproliferative activity against human SKHEP1 cells without FGFR4 gene amplification assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method
Antiproliferative activity against human SKHEP1 cells without FGFR4 gene amplification assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method
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[PMID: 30987781] |
FGFR4-IN-1 significantly inhibits the proliferation of HuH-7 hepatocellular carcinoma cells with IC50 of 13 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1708971-72-5
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性状 Solid
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分子量 493.52
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分子式 C24H27N7O5
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Color White to off-white
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SMILES
O=C(N1CCCC2=C1N=C(C=O)C(CN3C(COCC3)=O)=C2)NC4=NC=C(C#N)C(NCCOC)=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : 6.4 mg/mL (12.97 mM; Need warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
Methylene blue staining proliferation assay (MBS): The effect of compounds on cell proliferation is assessed using HuH-7 hepatocellular carcinoma cells are cultured in the vendor-recommended medium. Specifically, 5000 cells/well are seeded in 96-well tissue culture plates in a total media volume of 100 μL/well and increasing compound dilutions or DMSO are added 24 hours thereafter in triplicates. 72 hours after compound addition, cells are fixed by adding 25 and incubated for 10 minutes at room temperature. Cells are washed three times with H2O. Cells are washed 3 times with H2O, 200 mL/well and then lysed by adding 200 mL/well of 3% HCl for 30 minutes at room temperature with shaking. Optical density is measured at A650 nm. The concentration of compound providing 50% of proliferation inhibition with respect to DMSO-treated cells is determined (IC50) using XLFit software.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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データシート (274 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0263 mL | 10.1313 mL | 20.2626 mL | 50.6565 mL |
| 5 mM | 0.4053 mL | 2.0263 mL | 4.0525 mL | 10.1313 mL | |
| 10 mM | 0.2026 mL | 1.0131 mL | 2.0263 mL | 5.0657 mL |
FGFR4-IN-1 関連分類
HY-100631 関連分類
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