MC 1046
Based on 1 publication(s) in Google Scholar
MC 1046 (Impurity A of Calcipotriol) is a hepatic metabolite and an impurity of Calcipotriol (HY-10001). MC 1046 induces differentiation of histiocytic lymphoma cells. MC 1046 can be used for the research of histiocytic lymphoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 91.48%
- CAS 番号: 126860-83-1
- 分子式: C27H38O3
- 分子量:410.59
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保管条件:
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 MC 1046
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生物活性
MC 1046 (96 h) shows no measurable proliferation inhibition at concentrations up to 1.0×10-7 M and shows a differentiation-inducing concentration of 1.0×10-7 M in U 937 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human histiocytic lymphoma U 937 cells
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Concentration:1.0×10-7 M
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Incubation Time:96 h
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Result:Did not inhibit U 937 cell proliferation at the highest tested concentration of 1.0×10-7 M, resulting in an IC50 >1.0×10-7 M.
Induced cell differentiation at 1.0×10-7 M.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 126860-83-1
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性状 Solid
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分子量 410.59
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分子式 C27H38O3
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Color Off-white to yellow
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SMILES
C[C@]1(CCC/2)C(C2=C\C=C3C[C@@H](O)C[C@H](O)C\3=C)CC[C@@H]1[C@H](C)/C=C/C(C4CC4)=O
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別名
Impurity A of Calcipotriol
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Steroid Biochem Mol Biol
Pharmacokinetics of intra-articular vitamin D analogue calcipotriol in sheep and metabolism in human synovial and mesenchymal stromal cells. [Abstract]2019 Apr:188:172-184. PMID: 30562554
溶剤 & 溶解度
DMSO : 50 mg/mL (121.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kissmeyer AM, et al. Calcipotriol (MC 903): pharmacokinetics in rats and biological activities of metabolites. A comparative study with 1,25(OH)2D3. Biochem Pharmacol. 1991 Jun 1;41(11):1601-6. [Content Brief]
[2]. Crankshaw DL, et al. Effect of phenobarbital induction, charcoal treatment and storage on the spectral binding characteristics and NADPH-cytochrome P-450 reductase activity of hepatic microsomes. Biochem Pharmacol. 1990 Jan 15;39(2):393-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4355 mL | 12.1776 mL | 24.3552 mL | 60.8880 mL |
| 5 mM | 0.4871 mL | 2.4355 mL | 4.8710 mL | 12.1776 mL | |
| 10 mM | 0.2436 mL | 1.2178 mL | 2.4355 mL | 6.0888 mL | |
| 15 mM | 0.1624 mL | 0.8118 mL | 1.6237 mL | 4.0592 mL | |
| 20 mM | 0.1218 mL | 0.6089 mL | 1.2178 mL | 3.0444 mL | |
| 25 mM | 0.0974 mL | 0.4871 mL | 0.9742 mL | 2.4355 mL | |
| 30 mM | 0.0812 mL | 0.4059 mL | 0.8118 mL | 2.0296 mL | |
| 40 mM | 0.0609 mL | 0.3044 mL | 0.6089 mL | 1.5222 mL | |
| 50 mM | 0.0487 mL | 0.2436 mL | 0.4871 mL | 1.2178 mL | |
| 60 mM | 0.0406 mL | 0.2030 mL | 0.4059 mL | 1.0148 mL | |
| 80 mM | 0.0304 mL | 0.1522 mL | 0.3044 mL | 0.7611 mL | |
| 100 mM | 0.0244 mL | 0.1218 mL | 0.2436 mL | 0.6089 mL |
MC 1046 関連分類
HY-15264 関連分類
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