AHL-7160
AHL-7160 is a covalent DGKα inhibitor that possesses dual functions of enzyme activity inhibition (IC₅₀ ≈ 12 nM) and molecular gel-mediated degradation. AHL-7160 can rapidly recruit endogenous DGKα to the cell membrane (EC₅₀ = 39 nM), and this effect has isozyme selectivity. AHL-7160 can stereospecifically block phosphatidylcholine acid (PA) production mediated by DGKα (IC₅₀ = 340 nM). AHL-7160 enhances T cell activation and promotes anti-tumor immune responses. AHL-7160 can be used for research on immunotherapy.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C28H30N8O3S
- 分子量:558.65
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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ERK1 |
ERK2 |
IL-2 |
IL-5 |
IL-10 |
IL-17A |
化学情報
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分子量 558.65
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分子式 C28H30N8O3S
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SMILES
CN(C1=CC=C(C#N)N=C1C(N2C[C@@H](C)N(CC3=CC=C(S(N4C=NC(C5CC5)=N4)(=O)=O)C=C3)C[C@@H]2C)=C6)C6=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AHL-7160 関連分類
HY-180898 関連分類
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