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製品番号: HY-182571

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AK-42

AK-42 is a selective CLC-2 chloride channel inhibitor with human IC₅₀ of 17 nM and rat IC₅₀ of 14 nM. AK-42 binds to an extracellular vestibule above the channel pore, inhibits CLC-2 currents acutely and reversibly, including with auxiliary subunit GlialCAM coexpression. AK-42 acts as a selective tool compound for acute CLC-2 function modulation to probe CLC-2 neurophysiology. AK-42 can be used for the research of leukodystrophy and idiopathic generalized epilepsies.

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CAS 番号: 15437-29-3
分子式: C₂₀H₁₅Cl₂NO₃
分子量:388.24

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

AK-42 構造式

CAS 番号: 15437-29-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

CLC-2

14 (rat) nM (IC₅₀)

CLC-2

17 (human) nM (IC₅₀)

体外実験

AK-42 (5 min) potently inhibits human CLC-2 chloride currents stably expressed in CHO cells with an IC₅₀ of 17 nM, and displays >1000-fold selectivity over CLC-1 with minimal off-target activity against other CNS membrane proteins and anion channels^[1].
AK-42 potently and reversibly inhibits rat CLC-2 chloride currents transiently expressed in CHO cells with an IC₅₀ of 14 nM, with comparable efficacy against CLC-2 coexpressed with GlialCAM, and its binding is dependent on specific extracellular channel residues including K210 and Q399^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

アプリケーション

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

化学情報

CAS 番号 15437-29-3
分子量 388.24
分子式 C₂₀H₁₅Cl₂NO₃
SMILES

O=C(C1=C(NC2=C(Cl)C(OCC3=CC=CC=C3)=CC=C2Cl)C=CC=C1)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Koster AK, et al. Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel. Proc Natl Acad Sci U S A. 2020;117(51):32711-32721. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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