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製品番号: HY-184286

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Antifungal agent-167

Antifungal agent-167 is an Antifungal agent. Antifungal agent-167 promotes the release of cellular contents and impairs the permeability of fungal cell membranes. Antifungal agent-167 exhibits antifungal activity against Gaeumannomyces graminis and Colletotrichum orbiculare, with a EC₅₀ of 34.1 μg/mL against Colletotrichum orbiculare. Antifungal agent-167 can be used in studies related to Colletotrichum orbiculare infection.

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CAS 番号: 3116899-76-1
分子式: C₁₅H₁₉NO₅
分子量:293.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antifungal agent-167 構造式

CAS 番号: 3116899-76-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Antifungal agent-167 (Compound 3n) (7.5-120 μg/mL; 72 h) potently inhibits Colletotrichum orbiculare mycelium growth in vitro with an EC₅₀ of 34.1 μg/mL and a 60.9% inhibition rate at 50 μg/mL^[1].
Antifungal agent-167 (50 μg/mL; 72 h) inhibits Gaeumannomyces graminis mycelium growth in vitro with a 63.6% inhibition rate at 50 μg/mL^[1].
Antifungal agent-167 (15-60 μg/mL) increases cytoplasmic content release from Colletotrichum orbiculare mycelia in a concentration-dependent manner, damaging fungal cell membrane permeability^[1].
Antifungal agent-167 (15-30 μg/mL) exhibits moderate cytotoxicity to normal LO2 liver cells, with a cell survival rate of ~50% at 30 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3116899-76-1
分子量 293.32
分子式 C₁₅H₁₉NO₅
SMILES

OC1=CC(OCO2)=C2C=C1C(C(C)CN3CCOCC3)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Sui G, et al. Utilization of natural product for developing promising sterol biosynthesis inhibitors: design, synthesis and antifungal evaluation of cyclic trialkylamine derivatives. Bioorganic chemistry. 2026 Jun 08;180:110079. [Content Brief]

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