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製品番号: HY-187351

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BMX-IN-4

BMX-IN-4 is a covalent BMX kinase inhibitor with an IC₅₀ of 1.78 nM and a K_i of 0.158 μM. BMX-IN-4 forms a covalent bond with BMX kinase. BMX-IN-4 is applicable to the research of hepatocellular carcinoma.

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CAS 番号: 3132799-96-0
分子式: C₂₁H₁₅ClN₄O₂S
分子量:422.89

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

BMX-IN-4 構造式

CAS 番号: 3132799-96-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

BMX-IN-4 (Compound 11i) potently inhibits recombinant BMX with an IC₅₀ of 1.78 nM; it exhibits 2.3-fold selectivity over recombinant BTK, and its activity is dependent on a covalent warhead^[1].
BMX-IN-4 achieves selective cellular target binding to BMX but not BTK in HEK293T cells, with an EC₅₀ of 0.098 μM against BMX and a selectivity window of 20.6-fold^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3132799-96-0
分子量 422.89
分子式 C₂₁H₁₅ClN₄O₂S
SMILES

O=C(NC1=CN=C(C2=C1)NC=C2C3=CC=CC(NC(C=C)=O)=C3)C4=CC=C(S4)Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Liang XJ, et al. Riding toward Selectivity: Optimization of Covalent 7-Azaindole-Based BMX Kinase Inhibitors. Journal of medicinal chemistry. 2026 Jul 23;69(14):17416-17447. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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