2485758-50-5
2485758-50-5
Chemical Structure
JAK2/STAT3-IN-1
- CAS 番号: 2485758-50-5
- Formula:C34H35BrF3N5O2
- Molecular Weight:682.57
IUPAC Name: (S)-5-(1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-bromo-1H-indol-3-yl)-3-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide
InChIKey: ZTVCCTBSOVIZBK-YTTGMZPUSA-N
SMILES: O=C(N1N=C(C2=CC=C(C(F)(F)F)C=C2)C[C@H]1C3=CN(CC4=CC=C(OCCN5CCCCCC5)C=C4)C6=C3C=C(Br)C=C6)N
Biological Activity: JAK2/STAT3-IN-1 (compound (S)-10a) is a potent GP130 inhibitor with an IC50 of 3.04 µM. JAK2/STAT3-IN-1 shows anti-tumor activity[1].
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JAK2/STAT3-IN-1 | JAK2/STAT3-IN-1 (compound (S)-10a) is a potent GP130 inhibitor with an IC50 of 3.04 µM. JAK2/STAT3-IN-1 shows anti-tumor activity. | |||||||||||||||||||||
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References
Keywords
