530-08-5
Chemical Structure
Isoetharine
Synonym(s): Isoetarine
- CAS 番号: 530-08-5
- Formula:C13H21NO3
- Molecular Weight:239.31
IUPAC Name: 4-(1-hydroxy-2-(isopropylamino)butyl)benzene-1,2-diol
InChIKey: HUYWAWARQUIQLE-UHFFFAOYSA-N
SMILES: OC1=CC=C(C(O)C(NC(C)C)CC)C=C1O
Biological Activity: Isoetharine (Isoetarine) is an orally active selective agonist of β-adrenergic receptors. Isoetharine is a catechol-like agent and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator[1][2].
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Isoetharine | Isoetharine (Isoetarine) is an orally active selective agonist of β-adrenergic receptors. Isoetharine is a catechol-like agent and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator. | |||||||||||||||||||||
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- [1]. Katsuhisa Kurogi，et al. Concerted actions of the catechol O-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs. Biochem Pharmacol. 2012 Nov 1;84(9):1186-95. [Content Brief]
- [2]. Monika Maciag，et al. Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish. Toxicol Appl Pharmacol. 2022 Jan 1;434:115812. [Content Brief]
Keywords
