75-27-4
Chemical Structure
Bromodichloromethane
Synonym(s): Dichlorobromomethane
- CAS 番号: 75-27-4
- Formula:CHBrCl2
- Molecular Weight:163.83
IUPAC Name: bromodichloromethane
InChIKey: FMWLUWPQPKEARP-UHFFFAOYSA-N
SMILES: ClC(Br)Cl
Biological Activity: Bromodichloromethane (Dichlorobromomethane) is a type of trihalomethane, commonly found in chlorinated drinking water for disinfection, and is a disinfection by-product. The bromination of bromodichloromethane can cause the formation of mutagenic intermediates through the transformation mediated by glutathione S-transferase (GST). Bromodichloromethane inhibits the differentiation of human placental trophoblast cells and reduces the secretion of chorionic gonadotropin (CG). Bromodichloromethane has potential reproductive toxicity and carcinogenicity[1][2].
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Bromodichloromethane | Bromodichloromethane (Dichlorobromomethane) is a type of trihalomethane, commonly found in chlorinated drinking water for disinfection, and is a disinfection by-product. The bromination of bromodichloromethane can cause the formation of mutagenic intermediates through the transformation mediated by glutathione S-transferase (GST). Bromodichloromethane inhibits the differentiation of human placental trophoblast cells and reduces the secretion of chorionic gonadotropin (CG). Bromodichloromethane has potential reproductive toxicity and carcinogenicity. | |||||||||||||||||||||
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- [1]. Pegram RA, et al. Glutathione S-transferase-mediated mutagenicity of trihalomethanes in Salmonella typhimurium: contrasting results with bromodichloromethane off chloroform. Toxicol Appl Pharmacol. 1997 May;144(1):183-8. [Content Brief]
- [2]. Chen J, et al. Bromodichloromethane inhibits human placental trophoblast differentiation. Toxicol Sci. 2004 Mar;78(1):166-74. [Content Brief]
Keywords
