CHIR-29498
CHIR-29498 is an antibacterial peptoid. CHIR-29498 is active against both Gram-positive and Gram-negative bacteria. CHIR-29498 can be used for the study of fatal Staphylococcus aureus.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 236102-25-3
- 分子式: C38H55N5O3
- 分子量:629.88
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
CHIR-29498 (0.6-40 μM, 18-24 h) is active against both Gram-positive and Gram-negative bacteria[1].
CHIR-29498 (20-40 μM) can continuously increase the extracellular β-galactosidase activity of Escherichia coli ML-35 (ATCC 43827), indicating cell membrane leakage[1].
CHIR-29498 (20-40 μM, 0.5-2 h) causes 54.4% (1× MIC) and 74.2% (2× MIC) of Staphylococcus aureus ATCC 25923 to be stained with PI after incubation for 30 minutes; after 2 hours, the staining percentages increased to 78.1% and 94.1%, respectively, indicating increased membrane permeability. The effect of DHAA is relatively weak[1].
CHIR-29498 (1 h) induces hemolysis in mice (BALB/c) or human erythrocytes (RBCs) at concentrations above the MIC, but the hemolytic activity is mild[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female CD-1 mice (weighing approximately 25 grams) were inoculated with approximately 108 CFU of bacteria via intraperitoneal injection[1].
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Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg
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Administration:I.p., once
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Result:Protected 100% of the animals at a dose of 10 mg/kg.
Protected 50% of the animals when dosed (30 mg/kg) 110 min after i.p. infection.
化学情報
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CAS 番号 236102-25-3
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分子量 629.88
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分子式 C38H55N5O3
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SMILES
O=C(N(CC(N)=O)C1CCCC2=C1C=CC=C2)CN(CCN)C(CNC[C@]3(C)CCC[C@]4(C)C5=C(CC[C@@]34[H])C=C(C(C)C)C=C5)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CHIR-29498 関連分類
HY-118971 関連分類
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