COX-2-IN-69
COX-2-IN-69 is a selective, orally active COX-2 inhibitor with an IC50 of 0.90 μM. COX-2-IN-69 occupies the secondary pocket of COX-2, interacts with His90 and Arg513, and reduces serum levels of PGE2, IL-1β and TNF-α. COX-2-IN-69 exerts anti-inflammatory activity in a rat paw swelling model. COX-2-IN-69 can be used in inflammation-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C21H19BrN2O
- 分子量:395.29
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley (male, 130-150 g, Carrageenan (HY-125474)-induced paw edema model)[1]
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Dosage:10 mg/kg
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Administration:p.o.; single dose
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Result:Reduced paw edema percentage to 9.91% at 3 hours post-Carrageenan injection.
Showed no significant difference in paw volume compared to normal control at 2 and 3 hours.
Reduced serum PGE2 levels by 59.37%, serum IL-1β levels by 57.81%, and serum TNF-α levels by 54.70% compared to the Carrageenan control group.
Caused moderate desquamation of gastric mucosa, inflammatory cell infiltration of the submucosa layer, and vacuolar degeneration of gastric glands.
化学情報
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分子量 395.29
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分子式 C21H19BrN2O
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SMILES
BrC(C=C1)=CC=C1CC2=CC(/C=C/C3=C(C)C=C(C)C=C3)=NNC2=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
COX-2-IN-69 関連分類
HY-184710 関連分類
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