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製品番号: HY-106884

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Cyrtominetin

Cyrtominetin is a RANKL inhibitor with favorable ADMET properties. Cyrtominetin competitively blocks the binding of RANKL-RANK and increases the compactness of RANKL. Cyrtominetin can be used in studies related to osteoporosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 519-55-1
分子式: C₁₇H₁₆O₆
分子量:316.31

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cyrtominetin 構造式

CAS 番号: 519-55-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Cyrtominetin (100 ns) forms a complex with human RANKL that exhibits stable conformational dynamics over 100 ns of simulation, with an average backbone C_α-RMSD of 2.86 Å, increased compactness, stabilized active-site residues, and persistent hydrogen bonding interactions^[1].
Cyrtominetin (60-80 ns) binds to human RANKL with a highly favorable total binding free energy of -50.205 kJ/mol, stabilized by a combination of electrostatic and van der Waals interactions with specific active-site residues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 519-55-1
分子量 316.31
分子式 C₁₇H₁₆O₆
SMILES

OC1=C2C(O[C@@H](CC2=O)C3=CC(O)=C(O)C=C3)=C(C)C(O)=C1C
Structure Classification
- Flavonoids
- Flavonols
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zhang X, et al. Computational exploration of Eucommia ulmoides flavonoids as potential RANKL inhibitors via molecular docking and dynamics simulations. Scientific reports. 2025 May 17;15(1):17175. [Content Brief]

[2]. Zhang X, et al. Computational study of flavonoids from Eucommia ulmoides against RANKL-induced osteoclastogenesis using Molecular Docking and molecular dynamics simulation[J]. 2025.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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