FLT3-IN-22
FLT3-IN-22 (compound 22f) is a potent FLT3 inhibitor with IC50 values of 0.941 nM and 0.199 nM for FLT3 and FLT3/D835Y, respectively. FLT3-IN-22 exhibits strong antiproliferative activity against MV4-11 cells and the mutant FLT kinase expressed Ba/F3 cell lines, including FLT-D835Y and FLT3-F691L.
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- 分子式: C24H22N6O2
- 分子量:426.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 0.941 nM (FLT3) and 0.199 nM (FLT3/D835Y)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | GI50 |
866 nM
Compound: 22f
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Growth inhibition of mouse BaF3 cells measured after 72 hrs by alamar blue cell viability assay
Growth inhibition of mouse BaF3 cells measured after 72 hrs by alamar blue cell viability assay
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[PMID: 37866334] |
化学情報
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分子量 426.47
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分子式 C24H22N6O2
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SMILES
O=C(N[C@H]1CC[C@H](N)C1)C2=CC=C(NN=C3C4=NC5=C(C=C(C6=COC=C6)C=C5)N4)C3=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FLT3-IN-22 関連分類
HY-155302 関連分類
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