FTO-IN-15
FTO-IN-15 (Compound 8a) is a potent and selective dual-competitive FTO inhibitor with an IC50 of 43.7 nM, showing high selectivity over ALKBH3 and ALKBH5. FTO-IN-15 substantially inhibits FTO demethylation by simultaneously occupying the substrate and 2-oxoglutarate (2-OG) pockets. FTO-IN-15 can be used for the research of acute myeloid leukemia (AML).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C20H17Cl2N3O6
- 分子量:466.27
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 1.3 μM[1]
FTO-IN-15 (compound 8a) (0-50 μM) functions as a competitive inhibitor for the 2-OG binding pocket of FTO, as evidenced by the dose-dependent reversal of its inhibitory activity by increasing concentrations of 2-OG in a cell-free enzymatic assay[1].
FTO-IN-15 exhibits potent FTO inhibitory activity, with an IC50 of 43.7 nM in a cell-free dot blot assay and 1.3 μM in a PAGE-based demethylation assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 466.27
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分子式 C20H17Cl2N3O6
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SMILES
O=C(/C=C/C(NCCNC(C1=CC(Cl)=C(C(Cl)=C1)NC2=CC=CC=C2C(O)=O)=O)=O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FTO-IN-15 関連分類
HY-179266 関連分類
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