SPON2 - spondin 2 Gene

Also Known as DIL1; DIL-1; MINDIN; M-SPONDIN

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 10417

About SPON2

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,166,932-1,208,844 (from NCBI)

This gene has 22 transcripts (splice variants), 192 orthologues and 3 paralogues. Broad expression in prostate (RPKM 48.4), endometrium (RPKM 37.2) and 18 other tissues.

Summary

Predicted to enable antigen binding activity; lipopolysaccharide binding activity; and metal ion binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within several processes, including defense response to Other organism; opsonization; and positive regulation of cytokine production. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

SPON2 Products (3)

mRNA Protein Name
NM_001128325.3 NP_001121797.2 spondin-2 precursor
NM_001199021.2 NP_001185950.2 spondin-2 precursor
NM_012445.4 NP_036577.2 spondin-2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPON2 Protein Structure

Spond_N

Spond_N: Spondin_N (41 - 235)

  • 0
  • 100
  • 200
  • 300
  • 331 a.a.
Protein Preferred Names Protein Names

spondin-2

  • differentially expressed in cancerous and non-cancerous lung cells 1

SPON2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SPON2 Q9BUD6 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
SPON2 Q9BUD6 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
SPON2 Q9BUD6 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
SPON2 Q9BUD6 KLK6 Homo sapiens Q92876
Y2H Array
32814053
Intra
SPON2 Q9BUD6 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
Intra
SPON2 Q9BUD6 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
Intra
SPON2 Q9BUD6 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
SPON2 Q9BUD6 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Intra
SPON2 Q9BUD6 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Intra
SPON2 Q9BUD6 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
SPON2 Q9BUD6 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
SPON2 Q9BUD6 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPON2 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P70142 Spondin-2/SPON2 Protein, Human (HEK293, His) AAH02707.1 (Q27-V331) ≥ 95%, as determined by reducing SDS-PAGE.

SPON2 抗体

製品番号 製品名 アプリケーション 反応性
HY-P82304 SPON2 Antibody (YA2049) WB Human, Mouse, Rat
HY-P82304A SPON2 Antibody (YA2049)(PBS only) WB Human, Mouse, Rat

関連疾患

Diseases Alias
Pharyngitis

  • Acute Pharyngitis

  • Chronic Pharyngitis

  • Acute Sore Throat

  • Chronic Sore Throat

  • Persistent Sore Throat

  • Pharyngeal Diseases

  • Chronic Pharyn/Nasopharyngitis

  • Chronic Pharyngitis And Nasopharyngitis

  • Inflamed Throat

  • Pharyngeal Disease

  • Pharyngeal Disorder

  • Pharyngitis - Acute

  • Sore Throat - Chronic

  • Acute Pharyngitis Nos

  • Acute Sore Throat Nos

  • Acute Throat Inflammation

  • Infective Pharyngitis

  • Infection Of Pharynx

  • Acute Infective Pharyngitis

  • Acute Infective Pharyngitis Nos

  • Acute Pharyngeal Inflammation

  • Inflammation Of The Throat

  • Throat Inflammation

  • Throat Infection

  • Putrid Pharyngitis

  • Pharyngeal Inflammation

  • Pharyngitis Nos

  • Chronic Throat Pain

  • Throat Catarrh
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS13699 SPON2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19239 Spon2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25728 Spon2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus SPON2 MGD MGI:1923724
Bos taurus SPON2 VGNC VGNC:35228
Macaca mulatta SPON2 VGNC VGNC:82245
Felis catus SPON2 VGNC VGNC:80010
Canis familiaris SPON2 VGNC VGNC:59026
Rattus norvegicus SPON2 RGD RGD:708584
Others SPON2 NCBI