PAIP1 - poly(A) binding protein interacting protein 1 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 10605

About PAIP1

Cytogenetic location: 5p12 Genomic coordinates (GRCh38): 5:43,526,267-43,557,411 (from NCBI)

This gene has 10 transcripts (splice variants), 225 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 24.5), thyroid (RPKM 20.8) and 25 other tissues.

Summary

The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

PAIP1 Products (3)

mRNA Protein Name
NM_006451.5 NP_006442.2 polyadenylate-binding protein-interacting protein 1 isoform 1
NM_182789.4 NP_877590.1 polyadenylate-binding protein-interacting protein 1 isoform 2
NM_183323.3 NP_899152.1 polyadenylate-binding protein-interacting protein 1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
9548260 GOA
enables translation activator activity IDA
IDA: Inferred from direct assay
9548260 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in CRD-mediated mRNA stabilization IDA
IDA: Inferred from direct assay
11051545 GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
11051545 GOA
involved in positive regulation by host of viral process IDA
IDA: Inferred from direct assay
33876849 GOA
involved in positive regulation of cytoplasmic translation IDA
IDA: Inferred from direct assay
11051545 GOA
acts upstream of positive effect viral translation IDA
IDA: Inferred from direct assay
33876849 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
is active in cytoplasm IDA
IDA: Inferred from direct assay
33876849 GOA
located in cytosol IDA
IDA: Inferred from direct assay
11051545 GOA
part of mCRD-mediated mRNA stability complex IPI
IPI: Inferred from physical interaction
11051545 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAIP1 Protein Structure

PAM2

PAM2: Ataxin-2 C-terminal region (124 - 140)

MIF4G

MIF4G: MIF4G domain (160 - 376)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
Protein Preferred Names Protein Names

polyadenylate-binding protein-interacting protein 1

  • PABC1-interacting protein 1

PAIP1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
PAIP1 Q9H074 PABPC1 Homo sapiens P11940
SPR
14685257
Intra
PAIP1 Q9H074 PABPC1 Homo sapiens P11940
Y2H
9548260
Intra
PAIP1 Q9H074 PABPC1 Homo sapiens P11940
ITC
14685257
Intra
PAIP1 Q9H074 PABPC1 Homo sapiens P11940
CoIP
9548260
Intra
PAIP1 Q9H074 PABPC1 Homo sapiens P11940
Anti Tag CoIP
35271311
Intra
PAIP1 Q9H074 PABPC1 Homo sapiens P11940
Pull Down
11997512
Intra
PAIP1 Q9H074 PABPC1 Homo sapiens P11940
Anti Bait CoIP
11051545
Intra
PAIP1 Q9H074 PABPC1 Homo sapiens P11940
Pull Down
24396066
Intra
PAIP1 Q9H074 PABPC1 Homo sapiens P11940
Experimental Interac
9548260
Intra
PAIP1 Q9H074 PABPC1 Homo sapiens P11940
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

PAIP1 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81783 PAIP1 Antibody (YA1528) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P81783A PAIP1 Antibody (YA1528)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS09981 PAIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus PAIP1 MGD MGI:2384993
Macaca mulatta PAIP1 VGNC VGNC:84476
Rattus norvegicus PAIP1 RGD RGD:1305668
Others PAIP1 NCBI