DDN - dendrin Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 23109

About DDN

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:48,995,149-48,999,375 (from NCBI)

This gene has 1 transcript (splice variant) and 92 orthologues. Biased expression in brain (RPKM 36.7) and kidney (RPKM 8.9).

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in cell projection and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DDN Products (1)

mRNA Protein Name
NM_015086.2 NP_055901.2 dendrin

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
16464232 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cell projection IDA
IDA: Inferred from direct assay
16464232 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16464232 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDN Protein Structure

Dendrin

Dendrin: Nephrin and CD2AP-binding protein, Dendrin (55 - 709)

  • 0
  • 200
  • 400
  • 600
  • 711 a.a.
Protein Preferred Names Protein Names

dendrin

DDN Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
DDN O94850 SH3KBP1 Homo sapiens Q96B97
Y2H
16751601
Intra
DDN O94850 SH3KBP1 Homo sapiens Q96B97
Anti Bait CoIP
16751601
Intra
DDN O94850 SH3KBP1 Homo sapiens Q96B97
Pull Down
16751601
Cross
DDN O94850 Magi2 Rattus norvegicus O88382
Pull Down
16751601
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
46,Xy Sex Reversal 8

  • SRXY8

  • Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase

  • Tdd

  • 46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency

  • 46xy Sex Reversal 8

  • 46xy Sex Reversal 8, Modifier Of

  • Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase
Spondyloepiphyseal Dysplasia, Nishimura Type

  • SEDN

  • Spondyloepiphyseal Dysplasia Nishimura Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Phase
HY-138842 DDN Activator / Phase 3

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS03617 DDN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W744266 9α,10α-Epoxyhexahydrocannabinol / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus DDN RGD RGD:2497
Mus musculus DDN MGD MGI:108101
Canis familiaris DDN VGNC VGNC:39839
Macaca mulatta DDN VGNC VGNC:108335
Bos taurus DDN VGNC VGNC:27950
Felis catus DDN VGNC VGNC:61392
Others DDN NCBI