CABP2 - calcium binding protein 2 Gene

Also Known as DFNB93

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 51475

About CABP2

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,518,912-67,523,446 (from NCBI)

This gene has 4 transcripts (splice variants), 254 orthologues, 20 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene belongs to a subfamily of calcium binding proteins that share similarity to Calmodulin. Like Calmodulin, these family members can likely stimulate calmodulin-dependent kinase II and the protein phosphatase Calcineurin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

CABP2 Products (2)

mRNA	Protein	Name
NM_001318496.2	NP_001305425.1	calcium-binding protein 2 isoform 3
NM_016366.3	NP_057450.2	calcium-binding protein 2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19338761	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19338761	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CABP2 Protein Structure

EF-hand_1

EF-hand_7

0
100
200
220 a.a.

Protein Preferred Names	Protein Names
calcium-binding protein 2

CABP2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	CABP2	Q9NPB3	TEKT5	Homo sapiens	Q96M29	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	TEKT5	Homo sapiens	Q96M29	Y2H Array	32296183
Intra	CABP2	Q9NPB3	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ZNF774	Homo sapiens	Q6NX45	Y2H Array	32296183
Intra	CABP2	Q9NPB3	RD3	Homo sapiens	Q7Z3Z2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	RD3	Homo sapiens	Q7Z3Z2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	SPMIP6	Homo sapiens	Q8NCR6	Y2H Array	32296183
Intra	CABP2	Q9NPB3	SPMIP6	Homo sapiens	Q8NCR6	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	CARD9	Homo sapiens	Q9H257-2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	CARD9	Homo sapiens	Q9H257-2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	MXRA8	Homo sapiens	Q9BRK3	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	MXRA8	Homo sapiens	Q9BRK3	Y2H Array	32296183
Intra	CABP2	Q9NPB3	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	SPATC1L	Homo sapiens	Q9H0A9-2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	SPATC1L	Homo sapiens	Q9H0A9-2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ZNF140	Homo sapiens	P52738	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ZNF140	Homo sapiens	P52738	Y2H Array	32296183
Intra	CABP2	Q9NPB3	VXN	Homo sapiens	Q8TAG6	Y2H Array	32296183
Intra	CABP2	Q9NPB3	VXN	Homo sapiens	Q8TAG6	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	CIMIP1	Homo sapiens	Q9H1P6	Y2H Array	32296183
Intra	CABP2	Q9NPB3	CIMIP1	Homo sapiens	Q9H1P6	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
Intra	CABP2	Q9NPB3	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	UNKL	Homo sapiens	Q9H9P5-5	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	UNKL	Homo sapiens	Q9H9P5-5	Y2H Array	32296183
Intra	CABP2	Q9NPB3	NOP10	Homo sapiens	Q9NPE3	Validated Y2H	32296183
Intra	CABP2	Q9NPB3	NOP10	Homo sapiens	Q9NPE3	Y2H Array	32296183
Intra	CABP2	Q9NPB3	NOP10	Homo sapiens	Q9NPE3	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	HOXD12	Homo sapiens	P35452-2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ANKRD29	Homo sapiens	Q8N6D5	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ANKRD29	Homo sapiens	Q8N6D5	Y2H Array	32296183
Intra	CABP2	Q9NPB3	TRIM35	Homo sapiens	Q9UPQ4-2	Validated Y2H	32296183
Intra	CABP2	Q9NPB3	TRIM35	Homo sapiens	Q9UPQ4-2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	TRIM35	Homo sapiens	Q9UPQ4-2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	DPEP2NB	Homo sapiens	A0A0U1RQF7	Y2H Array	32296183
Intra	CABP2	Q9NPB3	DPEP2NB	Homo sapiens	A0A0U1RQF7	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	NDUFAF3	Homo sapiens	Q9BU61	Y2H Array	32296183
Intra	CABP2	Q9NPB3	NDUFAF3	Homo sapiens	Q9BU61	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	CABP2	Q9NPB3	COA6	Homo sapiens	Q5JTJ3	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	COA6	Homo sapiens	Q5JTJ3	Y2H Array	32296183
Intra	CABP2	Q9NPB3	NUDT16L1	Homo sapiens	Q9BRJ7	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	NUDT16L1	Homo sapiens	Q9BRJ7	Y2H Array	32296183
Intra	CABP2	Q9NPB3	ZNF785	Homo sapiens	A8K8V0	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ZNF785	Homo sapiens	A8K8V0	Y2H Array	32296183
Intra	CABP2	Q9NPB3	THAP6	Homo sapiens	Q8TBB0	Y2H Array	32296183
Intra	CABP2	Q9NPB3	THAP6	Homo sapiens	Q8TBB0	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	CABP2	Q9NPB3	C22orf39	Homo sapiens	Q6P5X5	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	C22orf39	Homo sapiens	Q6P5X5	Y2H Array	32296183
Intra	CABP2	Q9NPB3	NME4	Homo sapiens	O00746	Y2H Array	32296183
Intra	CABP2	Q9NPB3	NME4	Homo sapiens	O00746	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	TNNI1	Homo sapiens	P19237	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	TNNI1	Homo sapiens	P19237	Y2H Array	32296183
Intra	CABP2	Q9NPB3	ADGRF5	Homo sapiens	Q8IZF2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ADGRF5	Homo sapiens	Q8IZF2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	ZNF57	Homo sapiens	Q68EA5	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ZNF57	Homo sapiens	Q68EA5	Y2H Array	32296183
Intra	CABP2	Q9NPB3	AVPI1	Homo sapiens	Q5T686	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	AVPI1	Homo sapiens	Q5T686	Y2H Array	32296183
Intra	CABP2	Q9NPB3	SNAI2	Homo sapiens	O43623	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	SNAI2	Homo sapiens	O43623	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Deafness, Autosomal Recessive 93	DFNB93 Autosomal Recessive Nonsyndromic Deafness 93 Autosomal Recessive Deafness 93 Deafness, Autosomal Recessive, 93 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 93 Deafness, Autosomal Recessive, Type 93
Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb
Deafness, Autosomal Recessive
Autosomal Recessive Nonsyndromic Deafness	Deafness, Autosomal Recessive, Nonsyndromic
Deafness, Autosomal Dominant 2b	DFNA2B Autosomal Dominant Nonsyndromic Deafness 2b Autosomal Dominant Deafness 2b Deafness, Autosomal Dominant, 2b Deafness, Autosomal Dominant, Type 2b
Deafness, Autosomal Recessive 35	DFNB35 Autosomal Recessive Nonsyndromic Deafness 35 Autosomal Recessive Deafness 35 Deafness, Autosomal Recessive, 35 Deafness, Autosomal Recessive, Type 35
Deafness, Autosomal Recessive 6	DFNB6 Neurosensory Nonsyndromic Recessive Deafness 6 Nsrd6 Autosomal Recessive Nonsyndromic Deafness 6 Autosomal Recessive Deafness 6 Deafness, Autosomal Recessive, 6 Deafness Neurosensory Autosomal Recessive 6 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 6 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 6 Deafness, Autosomal Recessive, Type 6
Deafness, Autosomal Recessive 67	DFNB67 Autosomal Recessive Nonsyndromic Deafness 67 Autosomal Recessive Deafness 67 Deafness, Autosomal Recessive, 67 Deafness, Autosomal Recessive, Type 67
Charcot-Marie-Tooth Disease X-Linked Recessive 4	Cmt4x Cmtx4 Cowchock Syndrome X-Linked Charcot-Marie-Tooth Disease Type 4 Axonal Motor Sensory Neuropathy With Deafness And Mental Retardation Charcot-Marie-Tooth Disease With Deafness And Mental Retardation Nadmr Namsd
Melkersson-Rosenthal Syndrome	Melkersson Syndrome Mros Mrs Cheilitis Granulomatosa Of Mescher-Melkersson-Rosenthal Melkersson'S Syndrome Cheilitis Granulomatosa Granulomatous Cheilitis
Erythrokeratodermia Variabilis Et Progressiva 1	Erythrokeratodermia Variabilis Erythrokeratodermia Variabilis Et Progressiva Greither Disease Ekv Ekvp PSEK Erythrokeratodermia Variabilis With Erythema Gyratum Repens Keratosis Palmoplantaris Transgrediens Et Progrediens Transgrediens Et Progrediens Palmoplantar Keratoderma EKVP1 Erythrokeratodermia, Progressive Symmetric Erythrokeratodermia Figurata, Congenital Familial, In Plaques Keratoderma Palmoplantaris Transgrediens Keratosis Extremitatum Hereditaria Progrediens Erythrokeratodermia Variabilis, Mendes Da Costa Type Progressive Symmetric Erythrokeratodermia Erythrokeratodermia Figurata Variabilis Greither'S Disease Ekv-P Erythrokeratodermia Variabilis Of Mendes Da Costa Progressive Symmetrical Erythrokeratoderma Of Gottron Progressive Diffuse Ppk Progressive Diffuse Palmoplantar Keratoderma Transgrediens Et Progrediens Ppk Darier-Gottron Disease Erythrokeratodermia Progressiva Symmetrica Progressive Symmetric Erythrokeratodermia, Gottron Type Congenital Familial Erythrokeratodermia Figurata In Plaques Erythrokeratodermia Progressive Symmetric Erythrokeratodermia Variabilis Mendes Da Costa Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS01784	CABP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	CABP2	VGNC	VGNC:60286
Mus musculus	CABP2	MGD	MGI:1352749
Macaca mulatta	CABP2	VGNC	VGNC:70496
Rattus norvegicus	CABP2	RGD	RGD:1563670
Canis familiaris	CABP2	VGNC	VGNC:38624
Bos taurus	CABP2	VGNC	VGNC:26665
Others	CABP2	NCBI