PPP1CB - protein phosphatase 1 catalytic subunit beta Gene

Also Known as MP; PP1B; PP1c; NSLH2; PP-1B; PPP1CD; PP1beta; PPP1beta; HEL-S-80p

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 5500

About PPP1CB

Cytogenetic location: 2p23.2 Genomic coordinates (GRCh38): 2:28,751,604-28,802,940 (from NCBI)

This gene has 16 transcripts (splice variants), 213 orthologues, 12 paralogues and is associated with 3 phenotypes. Ubiquitous expression in esophagus (RPKM 80.9), prostate (RPKM 58.5) and 25 other tissues.

Summary

The protein encoded by this gene is one of the three catalytic subunits of protein Phosphatase 1 (PP1). PP1 is a serine/threonine specific protein Phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

PPP1CB Products (2)

mRNA Protein Name
NM_002709.3 NP_002700.1 serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform 1
NM_206876.2 NP_996759.1 serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform 1
Molecular Function GO Annotation Evidence 参考文献 由来
enables myosin-light-chain-phosphatase activity IDA
IDA: Inferred from direct assay
20354225 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11067852 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20354225 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in regulation of cell adhesion IDA
IDA: Inferred from direct assay
20354225 GOA
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
21712997 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of PTW/PP1 phosphatase complex IDA
IDA: Inferred from direct assay
20354225 GOA
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
24270157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1CB Protein Structure

Metallophos

Metallophos: Calcineurin-like phosphoesterase (58 - 249)

  • 0
  • 100
  • 200
  • 300
  • 327 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase PP1-beta catalytic subunit

  • epididymis secretory sperm binding protein Li 80p

PPP1CB Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435 28330616
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435 17353931
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435 28330616
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
TAP
27173435
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435 26496610
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435 27880917
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435 32296183
Intra
PPP1CB P62140 PPP1R2B Homo sapiens Q6NXS1 25416956
Intra
PPP1CB P62140 PPP1R2B Homo sapiens Q6NXS1 32296183
Intra
PPP1CB P62140 PPP1R2B Homo sapiens Q6NXS1 25416956
Intra
PPP1CB P62140 PPP1R2B Homo sapiens Q6NXS1 32296183
Intra
PPP1CB P62140 PPP1R16B Homo sapiens Q96T49 27107012
Intra
PPP1CB P62140 PPP1R11 Homo sapiens O60927 27880917
Intra
PPP1CB P62140 PPP1R11 Homo sapiens O60927 26496610
Intra
PPP1CB P62140 PPP1R11 Homo sapiens O60927
TAP
27173435
Intra
PPP1CB P62140 PPP1R11 Homo sapiens O60927 17353931
Intra
PPP1CB P62140 PPP1R11 Homo sapiens O60927 28330616
Intra
PPP1CB P62140 PPP1R11 Homo sapiens O60927 28330616
Intra
PPP1CB P62140 TP53BP2 Homo sapiens Q05BL1 32296183
Intra
PPP1CB P62140 TP53BP2 Homo sapiens Q05BL1 32296183
Intra
PPP1CB P62140 TP53BP2 Homo sapiens Q05BL1 32296183
Intra
PPP1CB P62140 SPATC1L Homo sapiens Q9H0A9-2 32296183
Intra
PPP1CB P62140 NRAC Homo sapiens Q8N912 32296183
Intra
PPP1CB P62140 PPP1R12B Homo sapiens A0A0S2Z4Q8 26871637
Intra
PPP1CB P62140 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
PPP1CB P62140 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
PPP1CB P62140 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1 25416956
Intra
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1 25416956
Intra
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1 32296183
Intra
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1 32296183
Intra
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1 32296183
Intra
PPP1CB P62140 KANK2 Homo sapiens Q63ZY3 32296183
Intra
PPP1CB P62140 KANK2 Homo sapiens Q63ZY3 32296183
Intra
PPP1CB P62140 KANK2 Homo sapiens Q63ZY3 32296183
Intra
PPP1CB P62140 PPP1R9B Homo sapiens Q96SB3 26496610
Intra
PPP1CB P62140 RRP1B Homo sapiens Q14684
TAP
27173435
Intra
PPP1CB P62140 CYSRT1 Homo sapiens A8MQ03 32296183
Intra
PPP1CB P62140 CYSRT1 Homo sapiens A8MQ03 32296183
Intra
PPP1CB P62140 CSRNP1 Homo sapiens Q96S65 32296183
Intra
PPP1CB P62140 CSRNP1 Homo sapiens Q96S65 32296183
Intra
PPP1CB P62140 SPRED1 Homo sapiens Q7Z699 32814053
Intra
PPP1CB P62140 SPRED1 Homo sapiens Q7Z699 32814053
Intra
PPP1CB P62140 SPRED1 Homo sapiens Q7Z699 32814053
Intra
PPP1CB P62140 PPP1R27 Homo sapiens Q86WC6 32296183
Intra
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175 32296183
Intra
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175 32296183
Intra
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175 25416956
Intra
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175 32296183
Intra
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175 32296183
Intra
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175 25416956
Intra
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5
TAP
27173435
Intra
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5 28330616
Intra
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5 28330616
Intra
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5 27880917
Intra
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5 26496610
Intra
PPP1CB P62140 PPP1R16A Homo sapiens Q96I34 28330616
Intra
PPP1CB P62140 PPP1R16A Homo sapiens Q96I34 25416956
Intra
PPP1CB P62140 PPP1R16A Homo sapiens Q96I34 25416956
Intra
PPP1CB P62140 PPP1R16A Homo sapiens Q96I34 32296183
Intra
PPP1CB P62140 PHACTR3 Homo sapiens Q96KR7 32296183
Intra
PPP1CB P62140 CHCHD3 Homo sapiens Q9NX63 32296183
Intra
PPP1CB P62140 CHCHD3 Homo sapiens Q9NX63 32296183
Intra
PPP1CB P62140 CHCHD3 Homo sapiens Q9NX63 32296183
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788 27107012
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788 17353931
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788 28330616
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788 27107012
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788 25416956
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788 27880917
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788 26496610
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788 28330616
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788 32296183
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
TAP
27173435
Cross: Cross-species interaction Intra: Intraspecies interaction

PPP1CB 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81958 PP1C beta Antibody (YA1703) WB, IHC-F, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat
HY-P81958A PP1C beta Antibody (YA1703)(PBS only) WB, IHC-F, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat
HY-P84427 PP1C beta Antibody (YA4124) WB, IHC-P, ICC/IF, FC, ELISA Human
HY-P84427A PP1C beta Antibody (YA4124)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human
HY-P85453 PP1C beta Antibody (YA5145) WB Human, Mouse, Rat, Chicken, Dog, Pig
HY-P86173 PP1C alpha/beta Antibody (YA5865) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

関連疾患

Diseases Alias
Noonan Syndrome-Like Disorder With Loose Anagen Hair 2
  • NSLH2

Noonan Syndrome-Like Disorder With Loose Anagen Hair
  • Noonan-Like Syndrome With Loose Anagen Hair

  • Mazzanti Syndrome

  • Ns/Lah

Pseudo-Turner Syndrome
  • Noonan Syndrome

Noonan Syndrome 1
  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male

Dandy-Walker Syndrome
  • Dandy-Walker Malformation

  • DWS

  • Atresia Of Foramina Of Magendie And Luschka

  • Dandy-Walker Complex

  • Dandy-Walker Cyst

  • Dandy-Walker Deformity

  • Dandy Walker Cyst

  • Dw Complex

  • Dandy-Walker Syndrome Or Malformation

  • Dandy-Walker Variant

  • Mega Cisterna Magna

  • Dwm

  • Hydrocephalus, Internal, Dandy-Walker Type

  • Hydrocephalus, Noncommunicating, Dandy-Walker Type

  • Luschka-Magendie Foramina Atresia

  • Isolated Dandy-Walker Malformation

  • Mega-Cisterna Magna

  • Dandy Walker Variant

  • Atresia Of Foramen Of Luschka

  • Atresia Of Foramen Of Magendie

  • Congenital Blockage Of Foramen Magendie

Rheumatoid Arthritis
  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis

Neurofibromatosis-Noonan Syndrome
  • NFNS

  • Neurofibromatosis Type 1

  • Neurofibromatosis With Noonan Phenotype

  • Nf1

  • Von Recklinghausen Disease

  • Neurofibromatosis Type 1-Noonan Syndrome

  • Noonan Neurofibromatosis Syndrome

  • Recklinghausen'S Disease

  • Noonan-Neurofibromatosis Syndrome

  • Fibromatosis Multiple Non Ossifying

  • Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots

  • Jaffe Campanacci Syndrome

  • Type 1 Neurofibromatosis

  • Neurofibromatosis 1

  • Peripheral Neurofibromatosis

  • Recklinghausen Disease, Nerve

  • Jaffe-Campanacci Syndrome

Rasopathy
  • Ras/Mitogen-Activated Protein Kinase Syndrome

Cardiofaciocutaneous Syndrome 1
  • Cardiofaciocutaneous Syndrome

  • Cfc Syndrome

  • Cardio-Facio-Cutaneous Syndrome

  • CFC1

  • Cfcs

  • Cardio-Facial-Cutaneous Syndrome

  • Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure

  • Cardiofaciocutaneous Syndrome, Type 1

Ptosis
  • Blepharoptosis

  • Drooping Eyelid

  • Droopy Eyelid

  • Ptosis Of Eyelid

  • Paralysis Of Levator Palpebrae Superioris

Noonan Syndrome With Multiple Lentigines
  • Leopard Syndrome

  • Multiple Lentigines Syndrome

  • Moynahan Syndrome

  • Cardiomyopathic Lentiginosis

  • Progressive Cardiomyopathic Lentiginosis

  • Cardio-Cutaneous Syndrome

  • Lentiginosis Profusa

  • Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

  • Generalized Lentiginosis

  • Gorlin Syndrome Ii

  • Lentiginosis Profusa Syndrome

  • Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

  • Diffuse Lentiginosis

  • Nsml

  • Familial Multiple Lentigines Syndrome

  • Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

  • Progressive Cardiomyopathic Lentiginosis Syndrome

  • Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus PPP1CB RGD RGD:3376
Canis familiaris PPP1CB VGNC VGNC:44875
Macaca mulatta PPP1CB VGNC VGNC:106197
Felis catus PPP1CB VGNC VGNC:68998
Mus musculus PPP1CB MGD MGI:104871
Bos taurus PPP1CB VGNC VGNC:33220
Others PPP1CB NCBI