PPP1CB - protein phosphatase 1 catalytic subunit beta Gene
Also Known as MP; PP1B; PP1c; NSLH2; PP-1B; PPP1CD; PP1beta; PPP1beta; HEL-S-80p
生物種: Homo sapiens
About PPP1CB
This gene has 16 transcripts (splice variants), 213 orthologues, 12 paralogues and is associated with 3 phenotypes. Ubiquitous expression in esophagus (RPKM 80.9), prostate (RPKM 58.5) and 25 other tissues.
Summary
The protein encoded by this gene is one of the three catalytic subunits of protein Phosphatase 1 (PP1). PP1 is a serine/threonine specific protein Phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
PPP1CB Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_002709.3 | NP_002700.1 | serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform 1 |
| NM_206876.2 | NP_996759.1 | serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform 1 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables myosin-light-chain-phosphatase activity |
IDA
IDA: Inferred from direct assay
|
20354225 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
11067852 | GOA |
| enables protein kinase binding |
IPI
IPI: Inferred from physical interaction
|
20354225 | GOA |
| Biological Process GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| involved in regulation of cell adhesion |
IDA
IDA: Inferred from direct assay
|
20354225 | GOA |
| involved in regulation of circadian rhythm |
IMP
IMP: Inferred from mutant phenotype
|
21712997 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| part of PTW/PP1 phosphatase complex |
IDA
IDA: Inferred from direct assay
|
20354225 | GOA |
| colocalizes with chromosome, telomeric region |
IDA
IDA: Inferred from direct assay
|
24270157 | GOA |
PPP1CB Protein Structure
Metallophos: Calcineurin-like phosphoesterase (58 - 249)
- 0
- 100
- 200
- 300
- 327 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
serine/threonine-protein phosphatase PP1-beta catalytic subunit |
|
PPP1CB Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
PPP1CB | P62140 | PPP1R7 | Homo sapiens | Q15435 | 28330616 | |
|
Intra
|
PPP1CB | P62140 | PPP1R7 | Homo sapiens | Q15435 | 17353931 | |
|
Intra
|
PPP1CB | P62140 | PPP1R7 | Homo sapiens | Q15435 | 28330616 | |
|
Intra
|
PPP1CB | P62140 | PPP1R7 | Homo sapiens | Q15435 | 27173435 | |
|
Intra
|
PPP1CB | P62140 | PPP1R7 | Homo sapiens | Q15435 | 26496610 | |
|
Intra
|
PPP1CB | P62140 | PPP1R7 | Homo sapiens | Q15435 | 27880917 | |
|
Intra
|
PPP1CB | P62140 | PPP1R7 | Homo sapiens | Q15435 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | PPP1R2B | Homo sapiens | Q6NXS1 | 25416956 | |
|
Intra
|
PPP1CB | P62140 | PPP1R2B | Homo sapiens | Q6NXS1 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | PPP1R2B | Homo sapiens | Q6NXS1 | 25416956 | |
|
Intra
|
PPP1CB | P62140 | PPP1R2B | Homo sapiens | Q6NXS1 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | PPP1R16B | Homo sapiens | Q96T49 | 27107012 | |
|
Intra
|
PPP1CB | P62140 | PPP1R11 | Homo sapiens | O60927 | 27880917 | |
|
Intra
|
PPP1CB | P62140 | PPP1R11 | Homo sapiens | O60927 | 26496610 | |
|
Intra
|
PPP1CB | P62140 | PPP1R11 | Homo sapiens | O60927 | 27173435 | |
|
Intra
|
PPP1CB | P62140 | PPP1R11 | Homo sapiens | O60927 | 17353931 | |
|
Intra
|
PPP1CB | P62140 | PPP1R11 | Homo sapiens | O60927 | 28330616 | |
|
Intra
|
PPP1CB | P62140 | PPP1R11 | Homo sapiens | O60927 | 28330616 | |
|
Intra
|
PPP1CB | P62140 | TP53BP2 | Homo sapiens | Q05BL1 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | TP53BP2 | Homo sapiens | Q05BL1 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | TP53BP2 | Homo sapiens | Q05BL1 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | SPATC1L | Homo sapiens | Q9H0A9-2 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | NRAC | Homo sapiens | Q8N912 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | PPP1R12B | Homo sapiens | A0A0S2Z4Q8 | 26871637 | |
|
Intra
|
PPP1CB | P62140 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | PPP1R3C | Homo sapiens | Q9UQK1 | 25416956 | |
|
Intra
|
PPP1CB | P62140 | PPP1R3C | Homo sapiens | Q9UQK1 | 25416956 | |
|
Intra
|
PPP1CB | P62140 | PPP1R3C | Homo sapiens | Q9UQK1 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | PPP1R3C | Homo sapiens | Q9UQK1 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | PPP1R3C | Homo sapiens | Q9UQK1 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | KANK2 | Homo sapiens | Q63ZY3 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | KANK2 | Homo sapiens | Q63ZY3 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | KANK2 | Homo sapiens | Q63ZY3 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | PPP1R9B | Homo sapiens | Q96SB3 | 26496610 | |
|
Intra
|
PPP1CB | P62140 | RRP1B | Homo sapiens | Q14684 | 27173435 | |
|
Intra
|
PPP1CB | P62140 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | CSRNP1 | Homo sapiens | Q96S65 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | CSRNP1 | Homo sapiens | Q96S65 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
PPP1CB | P62140 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
PPP1CB | P62140 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
PPP1CB | P62140 | PPP1R27 | Homo sapiens | Q86WC6 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | CSRNP2 | Homo sapiens | Q9H175 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | CSRNP2 | Homo sapiens | Q9H175 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | CSRNP2 | Homo sapiens | Q9H175 | 25416956 | |
|
Intra
|
PPP1CB | P62140 | CSRNP2 | Homo sapiens | Q9H175 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | CSRNP2 | Homo sapiens | Q9H175 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | CSRNP2 | Homo sapiens | Q9H175 | 25416956 | |
|
Intra
|
PPP1CB | P62140 | PPP1R13L | Homo sapiens | Q8WUF5 | 27173435 | |
|
Intra
|
PPP1CB | P62140 | PPP1R13L | Homo sapiens | Q8WUF5 | 28330616 | |
|
Intra
|
PPP1CB | P62140 | PPP1R13L | Homo sapiens | Q8WUF5 | 28330616 | |
|
Intra
|
PPP1CB | P62140 | PPP1R13L | Homo sapiens | Q8WUF5 | 27880917 | |
|
Intra
|
PPP1CB | P62140 | PPP1R13L | Homo sapiens | Q8WUF5 | 26496610 | |
|
Intra
|
PPP1CB | P62140 | PPP1R16A | Homo sapiens | Q96I34 | 28330616 | |
|
Intra
|
PPP1CB | P62140 | PPP1R16A | Homo sapiens | Q96I34 | 25416956 | |
|
Intra
|
PPP1CB | P62140 | PPP1R16A | Homo sapiens | Q96I34 | 25416956 | |
|
Intra
|
PPP1CB | P62140 | PPP1R16A | Homo sapiens | Q96I34 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | PHACTR3 | Homo sapiens | Q96KR7 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | CHCHD3 | Homo sapiens | Q9NX63 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | CHCHD3 | Homo sapiens | Q9NX63 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | CHCHD3 | Homo sapiens | Q9NX63 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | SH2D4A | Homo sapiens | Q9H788 | 27107012 | |
|
Intra
|
PPP1CB | P62140 | SH2D4A | Homo sapiens | Q9H788 | 17353931 | |
|
Intra
|
PPP1CB | P62140 | SH2D4A | Homo sapiens | Q9H788 | 28330616 | |
|
Intra
|
PPP1CB | P62140 | SH2D4A | Homo sapiens | Q9H788 | 27107012 | |
|
Intra
|
PPP1CB | P62140 | SH2D4A | Homo sapiens | Q9H788 | 25416956 | |
|
Intra
|
PPP1CB | P62140 | SH2D4A | Homo sapiens | Q9H788 | 27880917 | |
|
Intra
|
PPP1CB | P62140 | SH2D4A | Homo sapiens | Q9H788 | 26496610 | |
|
Intra
|
PPP1CB | P62140 | SH2D4A | Homo sapiens | Q9H788 | 28330616 | |
|
Intra
|
PPP1CB | P62140 | SH2D4A | Homo sapiens | Q9H788 | 32296183 | |
|
Intra
|
PPP1CB | P62140 | SH2D4A | Homo sapiens | Q9H788 | 27173435 |
PPP1CB 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P81958 | PP1C beta Antibody (YA1703) | WB, IHC-F, IHC-P, ICC/IF, FC, IP | Human, Mouse, Rat |
| HY-P81958A | PP1C beta Antibody (YA1703)(PBS only) | WB, IHC-F, IHC-P, ICC/IF, FC, IP | Human, Mouse, Rat |
| HY-P84427 | PP1C beta Antibody (YA4124) | WB, IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P84427A | PP1C beta Antibody (YA4124)(PBS only) | WB, IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P85453 | PP1C beta Antibody (YA5145) | WB | Human, Mouse, Rat, Chicken, Dog, Pig |
| HY-P86173 | PP1C alpha/beta Antibody (YA5865) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Noonan Syndrome-Like Disorder With Loose Anagen Hair 2 |
|
|
| Noonan Syndrome-Like Disorder With Loose Anagen Hair |
|
|
| Pseudo-Turner Syndrome |
|
|
| Noonan Syndrome 1 |
|
|
| Dandy-Walker Syndrome |
|
|
| Rheumatoid Arthritis |
|
|
| Neurofibromatosis-Noonan Syndrome |
|
|
| Rasopathy |
|
|
| Cardiofaciocutaneous Syndrome 1 |
|
|
| Ptosis |
|
|
| Noonan Syndrome With Multiple Lentigines |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Rattus norvegicus | PPP1CB | RGD | RGD:3376 |
| Canis familiaris | PPP1CB | VGNC | VGNC:44875 |
| Macaca mulatta | PPP1CB | VGNC | VGNC:106197 |
| Felis catus | PPP1CB | VGNC | VGNC:68998 |
| Mus musculus | PPP1CB | MGD | MGI:104871 |
| Bos taurus | PPP1CB | VGNC | VGNC:33220 |
| Others | PPP1CB | NCBI |