RRP1B - ribosomal RNA processing 1B Gene

Also Known as Nnp1; RRP1; NNP1L; KIAA0179; PPP1R136

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23076

About RRP1B

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:43,659,560-43,696,079 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 10.6), testis (RPKM 10.3) and 25 other tissues.

Summary

Enables transcription coactivator activity. Involved in several processes, including cellular response to virus; positive regulation by host of viral transcription; and positive regulation of transcription by RNA polymerase II. Located in chromosome; granular component; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RRP1B Products (1)

mRNA Protein Name
NM_015056.3 NP_055871.1 ribosomal RNA processing protein 1 homolog B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19389623 GOA
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
20040599 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to virus IDA
IDA: Inferred from direct assay
26311876 GOA
involved in positive regulation by host of viral transcription IMP
IMP: Inferred from mutant phenotype
26311876 GOA
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20040599 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20040599 GOA
Cellular Component GO Annotation Evidence References Source
located in granular component IDA
IDA: Inferred from direct assay
20926688 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
20040599 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRP1B Protein Structure

Nop52

Nop52: Nucleolar protein,Nop52 (9 - 219)

  • 0
  • 200
  • 400
  • 600
  • 758 a.a.
Protein Preferred Names Protein Names

ribosomal RNA processing protein 1 homolog B

  • RRP1-like protein B

RRP1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RRP1B Q14684 RRP1 Homo sapiens P56182
Anti Tag CoIP
20926688
Intra
RRP1B Q14684 PPP1CB Homo sapiens P62140
Anti Tag CoIP
20926688
Intra
RRP1B Q14684 RPL27 Homo sapiens P61353
Anti Tag CoIP
20926688
Intra
RRP1B Q14684 PPP1CC Homo sapiens P36873
Density Sedimentation
20926688
Intra
RRP1B Q14684 PPP1CC Homo sapiens P36873
Anti Tag CoIP
20926688
Intra
RRP1B Q14684 PPP1CA Homo sapiens P62136
Anti Tag CoIP
20926688
Intra
RRP1B Q14684 RPL5 Homo sapiens P46777
Anti Tag CoIP
20926688
Intra
RRP1B Q14684 FBL Homo sapiens P22087
Anti Tag CoIP
20926688
Intra
RRP1B Q14684 SRSF1 Homo sapiens Q07955
Anti Bait CoIP
23604122
Intra
RRP1B Q14684 SRSF1 Homo sapiens Q07955
Confocal
23604122
Intra
RRP1B Q14684 SRSF1 Homo sapiens Q07955
Anti Tag CoIP
23604122
Intra
RRP1B Q14684 SRSF1 Homo sapiens Q07955
Anti Tag CoIP
20926688
Intra
RRP1B Q14684 E2F1 Homo sapiens Q01094
BiFC
20040599
Intra
RRP1B Q14684 E2F1 Homo sapiens Q01094
Anti Tag CoIP
20040599
Intra
RRP1B Q14684 E2F1 Homo sapiens Q01094
CH-IP
20040599
Intra
RRP1B Q14684 E2F1 Homo sapiens Q01094
Pull Down
20040599
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microinvasive Gastric Cancer

  • Early Gastric Cancer

  • Surface Gastric Cancer
Laryngeal Squamous Cell Carcinoma

  • Epidermoid Carcinoma Of The Larynx

  • Squamous Cell Carcinoma Of Larynx

  • Squamous Cell Carcinoma Of The Larynx

  • Squamous Cell Carcinoma Of Head And Neck
Influenza

  • Flu

  • Influenza With Non-Respiratory Manifestation

  • Influenza With Other Manifestations

  • Influenza, Human

  • Influenza, Susceptibility To

  • Seasonal Influenza, Virus Identified
Osteogenesis Imperfecta, Type Xii

  • Osteogenesis Imperfecta Type 12

  • OI12

  • Osteogenesis Imperfecta Type Xii

  • Oi, Type Xii

  • Osteogenesis Imperfecta 12

  • Oi Type Xii

  • Oi-Xii

  • Osteogenesis Imperfecta Sillence Type Iii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12291 RRP1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RRP1B MGD MGI:1919712
Canis familiaris RRP1B VGNC VGNC:45766
Felis catus RRP1B VGNC VGNC:64781
Macaca mulatta RRP1B VGNC VGNC:77089
Rattus norvegicus RRP1B RGD RGD:1305633
Bos taurus RRP1B VGNC VGNC:34170
Others RRP1B NCBI