RPL5 - ribosomal protein L5 Gene

Also Known as L5; uL18; MSTP030; PPP1R135

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6125

About RPL5

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:92,831,986-92,841,924 (from NCBI)

This gene has 11 transcripts (splice variants), 226 orthologues and is associated with 59 phenotypes. Ubiquitous expression in ovary (RPKM 1433.7), thyroid (RPKM 620.7) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18P family of ribosomal proteins and component of the 60S subunit. The encoded protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The encoded protein may also function to inhibit tumorigenesis through the activation of downstream tumor suppressors and the downregulation of oncoprotein expression. Mutations in this gene have been identified in patients with Diamond-Blackfan Anemia (DBA). This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Mar 2017]

RPL5 Products (1)

mRNA	Protein	Name
NM_000969.5	NP_000960.2	60S ribosomal protein L5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 5S rRNA binding	IDA IDA: Inferred from direct assay	18560357	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	16213212	GOA
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	16213212	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9465063	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	18697920	GOA
enables ubiquitin ligase inhibitor activity	IDA IDA: Inferred from direct assay	18560357	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	18560357	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of protein neddylation	IDA IDA: Inferred from direct assay	18560357	GOA
involved in negative regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	18560357	GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	18560357	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18560357	GOA
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	16213212	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	18560357	GOA
involved in rRNA processing	IMP IMP: Inferred from mutant phenotype	18697920	GOA
involved in regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	24120868	GOA
involved in ribosomal large subunit assembly	IMP IMP: Inferred from mutant phenotype	24120868	GOA
involved in ribosomal large subunit biogenesis	IMP IMP: Inferred from mutant phenotype	18697920	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15314173	GOA
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	32669547	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	15469983	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	24120868	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9687515	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	15314173	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	18809582	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL5 Protein Structure

Ribosomal_L18p

Ribosomal_L18_c

0
100
200
297 a.a.

Protein Preferred Names	Protein Names
60S ribosomal protein L5	large ribosomal subunit protein uL18

RPL5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPL5	P46777	RPS23	Homo sapiens	P62266	Anti Tag CoIP	35271311
Intra	RPL5	P46777	RPS23	Homo sapiens	P62266	Density Sedimentation	20434207
Intra	RPL5	P46777	RPL23	Homo sapiens	P62829	Anti Tag CoIP	35271311
Intra	RPL5	P46777	RPL23	Homo sapiens	P62829	Crosslink	30021884
Intra	RPL5	P46777	RRP1B	Homo sapiens	Q14684	Anti Tag CoIP	35271311
Intra	RPL5	P46777	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	17110929
Intra	RPL5	P46777	SURF2	Homo sapiens	Q15527	Y2H	21900206
Intra	RPL5	P46777	SURF2	Homo sapiens	Q15527	Anti Tag CoIP	35271311
Cross	RPL5	P46777	Dcc	Rattus norvegicus	Q63155	Anti Bait CoIP	20434207
Cross	RPL5	P46777	Dcc	Rattus norvegicus	Q63155	Confocal	20434207

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Diamond-Blackfan Anemia 6	DBA6 Aase-Smith Syndrome Ii Aase Syndrome Aase Smith Syndrome 2 Rpl5-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 6 Diamond-Blackfan Anemia 1
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Atrial Heart Septal Defect	Atrial Septal Defect Atrial Septal Defects Atrioseptal Defect Auricular Septal Defect Congenital Atrial Septal Defect Interatrial Septal Defect Interauricular Septal Defect Heart Septal Defects, Atrial Septal Defect, Atrial
Diamond-Blackfan Anemia 1	Aase Syndrome DBA1 Erythrogenesis Imperfecta Aase-Smith Syndrome Ii Dba Blackfan-Diamond Syndrome Bds Anemia, Congenital Hypoplastic, Of Blackfan And Diamond Anemia, Congenital Erythroid Hypoplastic Red Cell Aplasia, Pure, Hereditary Aregenerative Anemia, Chronic Congenital Rps19-Related Diamond-Blackfan Anemia Chronic Congenital Aregenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Pure Hereditary Red Cell Aplasia Anemia, Diamond-Blackfan, Type 1 Anemia, Diamond-Blackfan Aase Smith Syndrome 2 Familial Hypoplastic Anaemia With Malformations Constitutional Pure Red Cell Aplasia
Hemangioma	Hemangiomas
Interatrial Communication	Asd Atrial Septal Defect Interauricular Communication
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Pulmonary Hypertension, Primary, 1	Pulmonary Arterial Hypertension Pah Idiopathic Pulmonary Arterial Hypertension Idiopathic Pulmonary Hypertension Primary Pulmonary Hypertension PPH1 Pulmonary Hypertension, Primary, Fenfluramine Or Dexfenfluramine-Associated Pulmonary Hypertension, Familial Primary, 1, With Or Without Hht Pph Familial Primary Pulmonary Hypertension Sporadic Primary Pulmonary Hypertension Pht Fpah Familial Pulmonary Arterial Hypertension Hereditary Pulmonary Arterial Hypertension Heritable Pulmonary Arterial Hypertension Ayerza Syndrome Fpph Ppht Ipah Primary Pulmonary Arterial Hypertension Pulmonary Hypertension, Familial Primary Hypertension, Pulmonary, Primary, Type 1 Ayerza'S Syndrome Pah - [Pulmonary Arterial Hypertension] Arrillaga Ayerza Syndrome
Macrocytic Anemia	Anemia Macrocytic Anemia, Macrocytic Macrocytic Anaemia
Shwachman-Diamond Syndrome 1	Shwachman-Diamond Syndrome Shwachman Syndrome Shwachman-Bodian-Diamond Syndrome Sds Pancreatic Insufficiency And Bone Marrow Dysfunction Shwachman-Bodian Syndrome SDS1 Lipomatosis Of Pancreas, Congenital Congenital Lipomatosis Of Pancreas Shwachman-Diamond Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia, Shwachman Type Shwachman-Diamond-Oski Syndrome
Dyskeratosis Congenita, X-Linked	DKCX X-Linked Dyskeratosis Congenita Zinsser-Cole-Engman Syndrome Hoyeraal-Hreidarsson Syndrome Dyskeratosis Congenita X-Linked HHS Cerebellar Hypoplasia With Pancytopenia Prenatal Growth Retardation With Progressive Pancytopenia And Cerebellar Hypoplasia Dyskeratosis Congenita
Bowen-Conradi Syndrome	BWCNS Bowen Hutterite Syndrome Bowen-Conradi Hutterite Syndrome Bowen Syndrome, Hutterite Type Bowen Hutterite Syndrome, Formerly Hutterite Syndrome Bowen Syndrome Hutterite Type Fetal Growth Retardation
Pure Red-Cell Aplasia	Pure Red Cell Aplasia Primary Red Cell Aplasia Red Cell Hypoplasia Prca Red-Cell Aplasia Pure Red-Cell Aplasia, Pure
Treacher Collins Syndrome 1	Treacher Collins Syndrome Mandibulofacial Dysostosis Treacher Collins-Franceschetti Syndrome Tcof Tcs Mfd1 Franceschetti-Klein Syndrome TCS1 Franceschetti Syndrome Franceschetti-Zwahlen-Klein Syndrome Zygoauromandibular Dysplasia Treacher-Collins Syndrome Mandibulofacial Dysostosis Without Limb Anomalies Bilateral And Symmetric Oto-Mandibular Dysplasia
Anauxetic Dysplasia 1	Anauxetic Dysplasia Spondylometaepiphyseal Dysplasia, Menger Type Spondylometaepiphyseal Dysplasia, Anauxetic Type Spondyloepimetaphyseal Dysplasia, Anauxetic Type ANXD1 Anxd Spondylometaepiphyseal Dysplasia Anauxetic Type Spondylometaepiphyseal Dysplasia Menger Type Ad Spondyloepimetaphyseal Dysplasia, Menger Type Dysplasia, Anauxetic, Type 1
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Orofacial Cleft	Cleft, Orofacial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12201	RPL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RPL5	VGNC	VGNC:54064
Rattus norvegicus	RPL5	RGD	RGD:619825
Macaca mulatta	RPL5	VGNC	VGNC:100065
Mus musculus	RPL5	MGD	MGI:102854
Others	RPL5	NCBI